Dosimetric Comparison of 6 MV and 15 MV Single Arc Rapidarc to Helical TomoTherapy for the Treatment of Pancreatic Cancer

Jing Cai; Jinbo Yue; Robert McLawhorn; Wensha Yang; Krishni Wijesooriya; Neal E. Dunlap; Ke Sheng; Fang Fang Yin; Stanley H. Benedict

doi:10.1016/j.meddos.2010.07.002

Dosimetric Comparison of 6 MV and 15 MV Single Arc Rapidarc to Helical TomoTherapy for the Treatment of Pancreatic Cancer

Jing Cai, Jinbo Yue, Robert McLawhorn, Wensha Yang, Krishni Wijesooriya, Neal E. Dunlap, Ke Sheng, Fang Fang Yin, Stanley H. Benedict

Research output: Journal article publication › Journal article › Academic research › peer-review

8 Citations (Scopus)

Abstract

We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with 6-MV beam (Plan_HT6), one using single-arc RA with 6-MV beam (Plan_RA6), and one using single-arc RA with 15-MV beam (Plan_RA15). Dosimetric indices including high/low conformality index (CI100%/CI50%), heterogeneity index (HI), monitor units (MUs), and doses to organs at risk (OARs) were compared. The mean CI100%was statistically equivalent with respect to the 2 treatment techniques, as well as beam energy (0.99, 1.01, and 1.02 for Plan_HT6, Plan_RA6, and Plan_RA156,respectively). The CI50%and HI were improved in both RA plans over the HT plan. The RA plans significantly reduced MU (MURA6= 697, MURA15= 548) compared with HT (MUHT6= 6177, p = 0.008 in both cases). The mean maximum cord dose was decreased from 29.6 Gy in Plan_HT6to 21.6 Gy (p = 0.05) in Plan_RA6and 21.7 Gy (p = 0.04) in Plan_RA15. The mean bowel dose decreased from 17.2 Gy in Plan_HT6to 15.2 Gy (p = 0.03) in Plan_RA6and 15.0 Gy (p = 0.03) Plan_RA15. The mean liver dose decreased from 8.4 Gy in Plan_HT6to 6.3 Gy (p = 0.04) in Plan_RA6and 6.2 Gy in Plan_RA15. Variations of the mean dose to the duodenum, kidneys, and stomach were statistically insignificant. RA and HT can both deliver conformal dose distributions to target volumes while limiting the dose to surrounding OARs in the treatment of pancreatic cancer. Dosimetric advantages might be gained by using RA over HT by reducing the dose to OARs and total MUs used for treatment.

Original language	English
Pages (from-to)	317-320
Number of pages	4
Journal	Medical Dosimetry
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.meddos.2010.07.002
Publication status	Published - 1 Jan 2011
Externally published	Yes

Keywords

Pancreatic cancer
RapidArc
Tomotherapy

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1016/j.meddos.2010.07.002

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@article{2f905094ecc14b91a5557948797a0de3,

title = "Dosimetric Comparison of 6 MV and 15 MV Single Arc Rapidarc to Helical TomoTherapy for the Treatment of Pancreatic Cancer",

abstract = "We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with 6-MV beam (Plan_HT6), one using single-arc RA with 6-MV beam (Plan_RA6), and one using single-arc RA with 15-MV beam (Plan_RA15). Dosimetric indices including high/low conformality index (CI100%/CI50%), heterogeneity index (HI), monitor units (MUs), and doses to organs at risk (OARs) were compared. The mean CI100%was statistically equivalent with respect to the 2 treatment techniques, as well as beam energy (0.99, 1.01, and 1.02 for Plan_HT6, Plan_RA6, and Plan_RA156,respectively). The CI50%and HI were improved in both RA plans over the HT plan. The RA plans significantly reduced MU (MURA6= 697, MURA15= 548) compared with HT (MUHT6= 6177, p = 0.008 in both cases). The mean maximum cord dose was decreased from 29.6 Gy in Plan_HT6to 21.6 Gy (p = 0.05) in Plan_RA6and 21.7 Gy (p = 0.04) in Plan_RA15. The mean bowel dose decreased from 17.2 Gy in Plan_HT6to 15.2 Gy (p = 0.03) in Plan_RA6and 15.0 Gy (p = 0.03) Plan_RA15. The mean liver dose decreased from 8.4 Gy in Plan_HT6to 6.3 Gy (p = 0.04) in Plan_RA6and 6.2 Gy in Plan_RA15. Variations of the mean dose to the duodenum, kidneys, and stomach were statistically insignificant. RA and HT can both deliver conformal dose distributions to target volumes while limiting the dose to surrounding OARs in the treatment of pancreatic cancer. Dosimetric advantages might be gained by using RA over HT by reducing the dose to OARs and total MUs used for treatment.",

keywords = "Pancreatic cancer, RapidArc, Tomotherapy",

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T1 - Dosimetric Comparison of 6 MV and 15 MV Single Arc Rapidarc to Helical TomoTherapy for the Treatment of Pancreatic Cancer

AU - Cai, Jing

AU - Yue, Jinbo

AU - McLawhorn, Robert

AU - Yang, Wensha

AU - Wijesooriya, Krishni

AU - Dunlap, Neal E.

AU - Sheng, Ke

AU - Yin, Fang Fang

AU - Benedict, Stanley H.

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N2 - We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with 6-MV beam (Plan_HT6), one using single-arc RA with 6-MV beam (Plan_RA6), and one using single-arc RA with 15-MV beam (Plan_RA15). Dosimetric indices including high/low conformality index (CI100%/CI50%), heterogeneity index (HI), monitor units (MUs), and doses to organs at risk (OARs) were compared. The mean CI100%was statistically equivalent with respect to the 2 treatment techniques, as well as beam energy (0.99, 1.01, and 1.02 for Plan_HT6, Plan_RA6, and Plan_RA156,respectively). The CI50%and HI were improved in both RA plans over the HT plan. The RA plans significantly reduced MU (MURA6= 697, MURA15= 548) compared with HT (MUHT6= 6177, p = 0.008 in both cases). The mean maximum cord dose was decreased from 29.6 Gy in Plan_HT6to 21.6 Gy (p = 0.05) in Plan_RA6and 21.7 Gy (p = 0.04) in Plan_RA15. The mean bowel dose decreased from 17.2 Gy in Plan_HT6to 15.2 Gy (p = 0.03) in Plan_RA6and 15.0 Gy (p = 0.03) Plan_RA15. The mean liver dose decreased from 8.4 Gy in Plan_HT6to 6.3 Gy (p = 0.04) in Plan_RA6and 6.2 Gy in Plan_RA15. Variations of the mean dose to the duodenum, kidneys, and stomach were statistically insignificant. RA and HT can both deliver conformal dose distributions to target volumes while limiting the dose to surrounding OARs in the treatment of pancreatic cancer. Dosimetric advantages might be gained by using RA over HT by reducing the dose to OARs and total MUs used for treatment.

AB - We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with 6-MV beam (Plan_HT6), one using single-arc RA with 6-MV beam (Plan_RA6), and one using single-arc RA with 15-MV beam (Plan_RA15). Dosimetric indices including high/low conformality index (CI100%/CI50%), heterogeneity index (HI), monitor units (MUs), and doses to organs at risk (OARs) were compared. The mean CI100%was statistically equivalent with respect to the 2 treatment techniques, as well as beam energy (0.99, 1.01, and 1.02 for Plan_HT6, Plan_RA6, and Plan_RA156,respectively). The CI50%and HI were improved in both RA plans over the HT plan. The RA plans significantly reduced MU (MURA6= 697, MURA15= 548) compared with HT (MUHT6= 6177, p = 0.008 in both cases). The mean maximum cord dose was decreased from 29.6 Gy in Plan_HT6to 21.6 Gy (p = 0.05) in Plan_RA6and 21.7 Gy (p = 0.04) in Plan_RA15. The mean bowel dose decreased from 17.2 Gy in Plan_HT6to 15.2 Gy (p = 0.03) in Plan_RA6and 15.0 Gy (p = 0.03) Plan_RA15. The mean liver dose decreased from 8.4 Gy in Plan_HT6to 6.3 Gy (p = 0.04) in Plan_RA6and 6.2 Gy in Plan_RA15. Variations of the mean dose to the duodenum, kidneys, and stomach were statistically insignificant. RA and HT can both deliver conformal dose distributions to target volumes while limiting the dose to surrounding OARs in the treatment of pancreatic cancer. Dosimetric advantages might be gained by using RA over HT by reducing the dose to OARs and total MUs used for treatment.

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Dosimetric Comparison of 6 MV and 15 MV Single Arc Rapidarc to Helical TomoTherapy for the Treatment of Pancreatic Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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