DNA-based bioanalytical microsystems for handheld device applications

Ming Hung Thomas Lee, I. Ming Hsing

Research output: Journal article publicationReview articleAcademic researchpeer-review

68 Citations (Scopus)

Abstract

This article reviews and highlights the current development of DNA-based bioanalytical microsystems for point-of-care diagnostics and on-site monitoring of food and water. Recent progresses in the miniaturization of various biological processing steps for the sample preparation, DNA amplification (polymerase chain reaction), and product detection are delineated in detail. Product detection approaches utilizing "portable" detection signals and electrochemistry-based methods are emphasized in this work. The strategies and challenges for the integration of individual processing module on the same chip are discussed.
Original languageEnglish
Pages (from-to)26-37
Number of pages12
JournalAnalytica Chimica Acta
Volume556
Issue number1
DOIs
Publication statusPublished - 18 Jan 2006
Externally publishedYes

Keywords

  • Bioanalytical microsystem
  • DNA
  • DNA amplification
  • Electrochemical detection
  • Lab-on-a-chip
  • Sample preparation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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