Distinct cell-specific control of autoimmunity and infection by FcγRIIb

Rebecca J. Brownlie, Kate E. Lawlor, Heather A. Niederer, Antony J. Cutler, Xiang Zou, Menna R. Clatworthy, R. Andres Floto, David R. Greaves, Paul A. Lyons, Kenneth G.C. Smith

Research output: Journal article publicationJournal articleAcademic researchpeer-review

145 Citations (Scopus)


FcγRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcγRIIb can modulate these processes, we created transgenic mice overexpressing FcγRIIb on B cells or macrophages. Overexpression of FcγRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcγRIIb in immune responses, demonstrate the contrasting roles played by FcγRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcγRIIb expression on B cells in inflammatory and autoimmune disease. JEM
Original languageEnglish
Pages (from-to)883-895
Number of pages13
JournalJournal of Experimental Medicine
Issue number4
Publication statusPublished - 14 Apr 2008
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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