Dissipative particle dynamics simulation of multiple deformable red blood cells in a vessel

Lanlan Xiao, Yang Liu, Shuo Chen, Bingmei Fu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

The blood flow properties in microvessels were examined through simulating the dynamics of deformable red blood cells suspended in plasma using dissipative particle dynamics. The cell membrane was considered as a spring-based triangulated network and the intercellular interaction was modeled by a Morse potential function. The cell distribution in the cross section indicated that red blood cells migrate away from the wall to the tube center, resulting in a cell-free layer near the wall and blunt velocity profile. The findings also showed that the bluntness of velocity profile increases with increasing hematocrit. In addition, the Fahraeus and Fahraeus-Lindqvist effects were captured through investigating the effects of tube diameter and hematocrit on the discharge hematocrit and relative apparent viscosity. It appears that this flow model can capture the blood flow behaviors under physiological and pathological conditions.

Original languageEnglish
Pages (from-to)303-313
Number of pages11
JournalInternational Journal of Computational Methods and Experimental Measurements
Volume6
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • Blood flow
  • Dissipative particle dynamics
  • Red blood cell

ASJC Scopus subject areas

  • Computational Mathematics
  • Computer Science Applications
  • Applied Mathematics
  • Modelling and Simulation
  • Computational Mechanics

Cite this