Dissemination of IncI2 plasmids that harbor the blaCTX-M element among clinical Salmonella isolates

Marcus Ho Yin Wong, Lizhang Liu, Meiying Yan, Edward Wai Chi Chan, Sheng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

30 Citations (Scopus)


The extended-spectrum-β-lactamase (ESBL) determinant CTX-M-55 is increasingly prevalent in Escherichia coli but remains extremely rare in Salmonella. This study reports the isolation of a plasmid harboring the blaCTX-M-55 element in a clinical Salmonella enterica serotype Typhimurium strain resistant to multiple antibiotics. This plasmid is genetically identical to several known IncI2-type elements harbored by E. coli strains recovered from animals. This finding indicates that IncI2 plasmids harboring the blaCTX-M genes may undergo cross-species migration among potential bacterial pathogens, with E. coli as the major source of such elements.
Original languageEnglish
Pages (from-to)5026-5028
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number8
Publication statusPublished - 1 Aug 2015

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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