Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity

Keyphrases

• Antitumor Agents 100%
• Inhibitory Activity 100%
• Chalcone Derivatives 100%
• Microtubule Polymerization 100%
• Quinoline-chalcones 100%
• Mitochondria 50%
• Antiproliferative Activity 50%
• M Phase 50%
• Induced Apoptosis 50%
• Toxic Effects 50%
• IC50 Value 50%
• Cancer Cell Lines 50%
• K562 Cells 50%
• Cancer Therapy 50%
• Tumor Growth 50%
• Mechanism Study 50%
• Tubulin 50%
• Intravenous Injection 50%
• Lethal Dose 50 (LD50) 50%
• Xenograft Model 50%
• Good Safety 50%
• Safety Profile 50%
• Stress Generation 50%
• Hydrochloride Salt 50%
• Anti-metastasis 50%
• Colchicine Binding Site 50%
• Reactive Oxidative Stress 50%
• Antivascular Therapy 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Chalcone Derivative 100%
• Antiproliferative Activity 50%
• Anticarcinogen 50%
• Toxicity 50%
• Tumor Growth 50%
• Tubulin 50%
• Colchicine 50%
• IC50 50%
• Table Salt 50%