Discovery of diagnostic serum biomarkers of gastric cancer using proteomics

Katie Wing Kei Lam, Chun Lap Samuel Lo

Research output: Journal article publicationReview articleAcademic researchpeer-review

26 Citations (Scopus)

Abstract

Gastric cancer has significant morbidity and mortality worldwide and locally. Good prognosis relies on an early diagnosis. However, this remains a challenge due to the lack of specific and sensitive serum biomarkers for early detection. Hence, there is a constant search for these biomarkers for screening purposes. Proteomic profiling enables a new approach to the discovery of biomarkers in disease. This review presents recent attempts in search of gastric cancer serum biomarker using proteomics. Different methodologies and different types of samples were employed by different groups of researchers. Major difficulties were encountered in the discovery processes, including interference from abundant proteins and continuous changing serum proteomes from different individuals. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)219-228
Number of pages10
JournalProteomics - Clinical Applications
Volume2
Issue number2
DOIs
Publication statusPublished - 1 Feb 2008

Keywords

  • Biomarker
  • Gastric cancer

ASJC Scopus subject areas

  • Clinical Biochemistry

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