Abstract
Purpose: To measure lung motion between end-inhalation and end-exhalation using a hyperpolarized helium-3 (HP3He) magnetic resonance (MR) tagging technique. Methods and Materials: Three healthy volunteers underwent MR tagging studies after inhalation of 1 L HP3He gas diluted with nitrogen. Multiple-slice two-dimensional and volumetric three-dimensional MR tagged images of the lungs were obtained at end-inhalation and end-exhalation, and displacement vector maps were computed. Results: The grids of tag lines in the HP3He MR images were well defined at end-inhalation and remained evident at end-exhalation. Displacement vector maps clearly demonstrated the regional lung motion and deformation that occurred during exhalation. Discontinuity and differences in motion pattern between two adjacent lung lobes were readily resolved. Conclusions: Hyperpolarized helium-3 MR tagging technique can be used for direct in vivo measurement of respiratory lung motion on a regional basis. This technique may lend new insights into the regional pulmonary biomechanics and thus provide valuable information for the deformable registration of lung.
Original language | English |
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Pages (from-to) | 650-653 |
Number of pages | 4 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 68 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jul 2007 |
Externally published | Yes |
Keywords
- Deformable registration
- Hyperpolarized helium-3
- Lung motion
- MR tagging
ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research