Direct aldol and tandem Mannich reactions in room temperature ammonia solutions

Lichun Feng, Lijin Xu, Kimhung Lam, Zhongyuan Zhou, C. W. Yip, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)


An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, and indole-3-carboxyaldehyde were employed to afford 2,2-dimethyl-6-aryl-4-pyrilidinones in moderate to good yields.

Original languageEnglish
Pages (from-to)8685-8689
Number of pages5
JournalTetrahedron Letters
Issue number50
Publication statusPublished - 12 Dec 2005


  • Aldol reaction
  • Ammonia solutions
  • Mannich reaction
  • Tandem

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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