Direct aldol and tandem Mannich reactions in room temperature ammonia solutions

Lichun Feng; Lijin Xu; Kimhung Lam; Zhongyuan Zhou; C. W. Yip; Albert S.C. Chan

doi:10.1016/j.tetlet.2005.10.050

Direct aldol and tandem Mannich reactions in room temperature ammonia solutions

Lichun Feng, Lijin Xu, Kimhung Lam, Zhongyuan Zhou, C. W. Yip, Albert S.C. Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

11 Citations (Scopus)

Abstract

An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, and indole-3-carboxyaldehyde were employed to afford 2,2-dimethyl-6-aryl-4-pyrilidinones in moderate to good yields.

Original language	English
Pages (from-to)	8685-8689
Number of pages	5
Journal	Tetrahedron Letters
Volume	46
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2005.10.050
Publication status	Published - 12 Dec 2005

Keywords

Aldol reaction
Ammonia solutions
Mannich reaction
Tandem

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

More information

10.1016/j.tetlet.2005.10.050

Cite this

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abstract = "An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, and indole-3-carboxyaldehyde were employed to afford 2,2-dimethyl-6-aryl-4-pyrilidinones in moderate to good yields.",

keywords = "Aldol reaction, Ammonia solutions, Mannich reaction, Tandem",

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T1 - Direct aldol and tandem Mannich reactions in room temperature ammonia solutions

AU - Feng, Lichun

AU - Xu, Lijin

AU - Lam, Kimhung

AU - Zhou, Zhongyuan

AU - Yip, C. W.

AU - Chan, Albert S.C.

PY - 2005/12/12

Y1 - 2005/12/12

N2 - An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, and indole-3-carboxyaldehyde were employed to afford 2,2-dimethyl-6-aryl-4-pyrilidinones in moderate to good yields.

AB - An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, and indole-3-carboxyaldehyde were employed to afford 2,2-dimethyl-6-aryl-4-pyrilidinones in moderate to good yields.

KW - Aldol reaction

KW - Ammonia solutions

KW - Mannich reaction

KW - Tandem

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U2 - 10.1016/j.tetlet.2005.10.050

DO - 10.1016/j.tetlet.2005.10.050

M3 - Journal article

AN - SCOPUS:27744571730

SN - 0040-4039

VL - 46

SP - 8685

EP - 8689

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

Direct aldol and tandem Mannich reactions in room temperature ammonia solutions

Abstract

Keywords

ASJC Scopus subject areas

More information

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