Diffusion tensor MR study of optic nerve degeneration in glaucoma

Edward S. Hui; Qing Ling Fu; Kwok Fai So; Ed X. Wu

doi:10.1109/IEMBS.2007.4353290

Diffusion tensor MR study of optic nerve degeneration in glaucoma

Edward S. Hui
, Qing Ling Fu
, Kwok Fai So
, Ed X. Wu

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

45 Citations (Scopus)

Abstract

Axonal degeneration has been known to occur in the optic nerve (ON) of rat glaucoma model. Recently, quantitative diffusion tensor imaging (DTI) has been developed to investigate various white matter diseases in vivo. In this study, longitudinal DTI was thus employed to study such animal model in the present study. The results showed that radial diffusivity (λ⊥) and fractional anisotropy (FA) of the glaucomatous ON (gON) was increasing and decreasing respectively with time after glaucoma induction, whereas there was no significant change in the axial diffusivity (λ _//). Supported by the histological staining of the ON, such changes in the two DTI-derived parameters were attributed to the 10% decrease in the axonal density of the gON as compared to nON. It was shown for the first time that DTI can be sensitive enough to detect axonal degeneration in rat glaucoma model. DTI therefore holds promise for reliable diagnoses and assessment of the glaucoma disease in human upon careful interpretation of the DTI-derived directional diffusivities.

Original language	English
Title of host publication	29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Pages	4312-4315
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2007.4353290
Publication status	Published - Nov 2007
Externally published	Yes
Event	29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France Duration: 23 Aug 2007 → 26 Aug 2007

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)	0589-1019

Conference

Conference	29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Country/Territory	France
City	Lyon
Period	23/08/07 → 26/08/07

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diffusivity
DTI
Glaucoma
Neurodegeneration

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

More information

10.1109/IEMBS.2007.4353290

Cite this

Hui, E. S., Fu, Q. L., So, K. F., & Wu, E. X. (2007). Diffusion tensor MR study of optic nerve degeneration in glaucoma. In 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 (pp. 4312-4315). Article 4353290 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2007.4353290

@inproceedings{79dc9dc182c34ce0b04cdc72869d2384,

title = "Diffusion tensor MR study of optic nerve degeneration in glaucoma",

abstract = "Axonal degeneration has been known to occur in the optic nerve (ON) of rat glaucoma model. Recently, quantitative diffusion tensor imaging (DTI) has been developed to investigate various white matter diseases in vivo. In this study, longitudinal DTI was thus employed to study such animal model in the present study. The results showed that radial diffusivity (λ⊥) and fractional anisotropy (FA) of the glaucomatous ON (gON) was increasing and decreasing respectively with time after glaucoma induction, whereas there was no significant change in the axial diffusivity (λ //). Supported by the histological staining of the ON, such changes in the two DTI-derived parameters were attributed to the 10\% decrease in the axonal density of the gON as compared to nON. It was shown for the first time that DTI can be sensitive enough to detect axonal degeneration in rat glaucoma model. DTI therefore holds promise for reliable diagnoses and assessment of the glaucoma disease in human upon careful interpretation of the DTI-derived directional diffusivities.",

keywords = "Diffusivity, DTI, Glaucoma, Neurodegeneration",

author = "Hui, \{Edward S.\} and Fu, \{Qing Ling\} and So, \{Kwok Fai\} and Wu, \{Ed X.\}",

note = "Copyright: Copyright 2012 Elsevier B.V., All rights reserved.; 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 ; Conference date: 23-08-2007 Through 26-08-2007",

year = "2007",

month = nov,

doi = "10.1109/IEMBS.2007.4353290",

language = "English",

isbn = "1424407885",

series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

pages = "4312--4315",

booktitle = "29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07",

}

Hui, ES, Fu, QL, So, KF & Wu, EX 2007, Diffusion tensor MR study of optic nerve degeneration in glaucoma. in 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07., 4353290, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, pp. 4312-4315, 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07, Lyon, France, 23/08/07. https://doi.org/10.1109/IEMBS.2007.4353290

Diffusion tensor MR study of optic nerve degeneration in glaucoma. / Hui, Edward S.; Fu, Qing Ling; So, Kwok Fai et al.
29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07. 2007. p. 4312-4315 4353290 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

TY - GEN

T1 - Diffusion tensor MR study of optic nerve degeneration in glaucoma

AU - Hui, Edward S.

AU - Fu, Qing Ling

AU - So, Kwok Fai

AU - Wu, Ed X.

PY - 2007/11

Y1 - 2007/11

N2 - Axonal degeneration has been known to occur in the optic nerve (ON) of rat glaucoma model. Recently, quantitative diffusion tensor imaging (DTI) has been developed to investigate various white matter diseases in vivo. In this study, longitudinal DTI was thus employed to study such animal model in the present study. The results showed that radial diffusivity (λ⊥) and fractional anisotropy (FA) of the glaucomatous ON (gON) was increasing and decreasing respectively with time after glaucoma induction, whereas there was no significant change in the axial diffusivity (λ //). Supported by the histological staining of the ON, such changes in the two DTI-derived parameters were attributed to the 10% decrease in the axonal density of the gON as compared to nON. It was shown for the first time that DTI can be sensitive enough to detect axonal degeneration in rat glaucoma model. DTI therefore holds promise for reliable diagnoses and assessment of the glaucoma disease in human upon careful interpretation of the DTI-derived directional diffusivities.

AB - Axonal degeneration has been known to occur in the optic nerve (ON) of rat glaucoma model. Recently, quantitative diffusion tensor imaging (DTI) has been developed to investigate various white matter diseases in vivo. In this study, longitudinal DTI was thus employed to study such animal model in the present study. The results showed that radial diffusivity (λ⊥) and fractional anisotropy (FA) of the glaucomatous ON (gON) was increasing and decreasing respectively with time after glaucoma induction, whereas there was no significant change in the axial diffusivity (λ //). Supported by the histological staining of the ON, such changes in the two DTI-derived parameters were attributed to the 10% decrease in the axonal density of the gON as compared to nON. It was shown for the first time that DTI can be sensitive enough to detect axonal degeneration in rat glaucoma model. DTI therefore holds promise for reliable diagnoses and assessment of the glaucoma disease in human upon careful interpretation of the DTI-derived directional diffusivities.

KW - Diffusivity

KW - DTI

KW - Glaucoma

KW - Neurodegeneration

UR - https://www.scopus.com/pages/publications/57649225851

U2 - 10.1109/IEMBS.2007.4353290

DO - 10.1109/IEMBS.2007.4353290

M3 - Conference article published in proceeding or book

C2 - 18002956

AN - SCOPUS:57649225851

SN - 1424407885

SN - 9781424407880

T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

SP - 4312

EP - 4315

BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07

T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07

Y2 - 23 August 2007 through 26 August 2007

ER -

Diffusion tensor MR study of optic nerve degeneration in glaucoma

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this