Differential single living cell refractometry using grating resonant cavity with optical trap

L. K. Chin; A. Q. Liu; C. S. Lim; Xuming Zhang; J. H. Ng; J. Z. Hao; S. Takahashi

doi:10.1063/1.2823610

Differential single living cell refractometry using grating resonant cavity with optical trap

L. K. Chin, A. Q. Liu, C. S. Lim, Xuming Zhang, J. H. Ng, J. Z. Hao, S. Takahashi

Research output: Journal article publication › Journal article › Academic research › peer-review

64 Citations (Scopus)

Abstract

This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage.

Original language	English
Article number	243901
Journal	Applied Physics Letters
Volume	91
Issue number	24
DOIs	https://doi.org/10.1063/1.2823610
Publication status	Published - 20 Dec 2007
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1063/1.2823610

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abstract = "This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage.",

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AU - Chin, L. K.

AU - Liu, A. Q.

AU - Lim, C. S.

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AU - Ng, J. H.

AU - Hao, J. Z.

AU - Takahashi, S.

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N2 - This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage.

AB - This letter reports the measurement of single living cell's refractive index (RI) using the optical grating resonant cavity with buffer modulation on a biochip. The cell's RI is a significant cell biophysical property which has potential in cancer and disease diagnoses. The single cell is trapped optically within the cavity, and the transmission spectra shift due to the change of surrounding buffer, without/with cell, are used to determine the cell's effective RI and effective thickness. The measurement shows that Madin-Darby canine kidney cell has an effective RI of 1.383±0.001. Moreover, the optical trapping technique eliminates uncertainty and avoids cell damage.

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JO - Applied Physics Letters

JF - Applied Physics Letters

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ER -

Differential single living cell refractometry using grating resonant cavity with optical trap

Abstract

ASJC Scopus subject areas

UN SDGs

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