Differential protein expression induced by a lipid extract of Perna canaliculus in splenocytes of rats with adjuvant-induced arthritis

C. H. Lee, Y. K.C. Butt, Man Sau Wong, Chun Lap Samuel Lo

Research output: Journal article publicationJournal articleAcademic researchpeer-review

3 Citations (Scopus)

Abstract

The lipid extract of Perna canaliculus (Lyprinol®) has known anti-inflammatory effects. However, the only information on mechanisms is regulation of cytokine secretion. Therefore, we conducted a proteomic study exploring the effects of Lyprinol on protein expression in splenocytes collected from AIA rats. Splenocytes from AIA rats fed with Lyprinol had increased protein expression of malate dehydrogenase (MDH). Lyprinol also decreased the expressions of 5 other proteins: protein-o-mannosyl- transferase 2 (PMT-2), Tdrd 7, telethonin, dynactin 2 and protein disulfide isomerase (PDI or glucose-regulated protein (GRP)). Besides MDH, PMT- 2, titin-cap protein and protein disulfide isomerase (PDI) are known to be related to metabolism. However, it is currently unknown if Lyprinol administration decreases metabolic glucose in the body and alleviates symptoms of inflammation and arthritis. Further experiments are required to correlate levels of citric acid intermediates and glucose to the severity of inflammation and pain in AIA rats fed Lyprinol.
Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalInflammopharmacology
Volume16
Issue number4
DOIs
Publication statusPublished - 1 Aug 2008

Keywords

  • Adjuvant-induced arthritis
  • Lyprinol
  • Malate dehydrogenase
  • Protein disulfide isomerase
  • Protein-o-mannoyl-transferase
  • Proteomics
  • Tdrd7 protein
  • Titin-cap protein

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

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