Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells

W. Z. Song; C. S. Lim; P. H. Yap; A. Q. Liu

doi:10.1109/SENSOR.2007.4300594

Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells

W. Z. Song, C. S. Lim, P. H. Yap, A. Q. Liu

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

1 Citation (Scopus)

Abstract

This paper represents a differential method for simultaneously measuring the refractive index (RI) and the size of single living cells using the fiber-based Mach-Zehnder interferometer and optical trapping; both are integrated onto an optofluidic chip. In experiment, a living cancerous cell MDCK is trapped by 45-mW laser light and then the cell's refractive index and diameter are simultaneously determined by the spectral shift in response to the buffer modulation and cell presence/absence. The measured cell has a size of 15.1 μm and a RI of 1.397 at an accuracy of 0.1%.

Original language	English
Title of host publication	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	2159-2162
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2007.4300594
Publication status	Published - Jun 2007
Externally published	Yes
Event	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France Duration: 10 Jun 2007 → 14 Jun 2007

Publication series

Name	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Conference

Conference	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
Country/Territory	France
City	Lyon
Period	10/06/07 → 14/06/07

Keywords

Living cells
Mach-Zehnder interferometer
Optofluidics
Refractive index

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering

More information

10.1109/SENSOR.2007.4300594

Cite this

Song, W. Z., Lim, C. S., Yap, P. H., & Liu, A. Q. (2007). Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 2159-2162). Article 4300594 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300594

Song, W. Z. ; Lim, C. S. ; Yap, P. H. et al. / Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells. TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. pp. 2159-2162 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

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abstract = "This paper represents a differential method for simultaneously measuring the refractive index (RI) and the size of single living cells using the fiber-based Mach-Zehnder interferometer and optical trapping; both are integrated onto an optofluidic chip. In experiment, a living cancerous cell MDCK is trapped by 45-mW laser light and then the cell's refractive index and diameter are simultaneously determined by the spectral shift in response to the buffer modulation and cell presence/absence. The measured cell has a size of 15.1 μm and a RI of 1.397 at an accuracy of 0.1%.",

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Song, WZ, Lim, CS, Yap, PH & Liu, AQ 2007, Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells. in TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems., 4300594, TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 2159-2162, 4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07, Lyon, France, 10/06/07. https://doi.org/10.1109/SENSOR.2007.4300594

Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells. / Song, W. Z.; Lim, C. S.; Yap, P. H. et al.
TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 2159-2162 4300594 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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AB - This paper represents a differential method for simultaneously measuring the refractive index (RI) and the size of single living cells using the fiber-based Mach-Zehnder interferometer and optical trapping; both are integrated onto an optofluidic chip. In experiment, a living cancerous cell MDCK is trapped by 45-mW laser light and then the cell's refractive index and diameter are simultaneously determined by the spectral shift in response to the buffer modulation and cell presence/absence. The measured cell has a size of 15.1 μm and a RI of 1.397 at an accuracy of 0.1%.

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Song WZ, Lim CS, Yap PH, Liu AQ. Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 2159-2162. 4300594. (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2007.4300594

Differential Mach-Zehnder interferometer for simultaneously determining size and refractive index of living cells

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