Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging

J. A. Jo; Q. Fang; T. Papaioannou; J. H. Qiao; M. C. Fishbein; B. Beseth; A. H. Dorafshar; T. Reil; D. Baker; J. Freischlag; K. K. Shung; Lei Sun; L. Marcu

doi:10.1109/IEMBS.2006.259350

Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging

J. A. Jo, Q. Fang, T. Papaioannou, J. H. Qiao, M. C. Fishbein, B. Beseth, A. H. Dorafshar, T. Reil, D. Baker, J. Freischlag, K. K. Shung, Lei Sun, L. Marcu

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

6 Citations (Scopus)

Abstract

In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.

Original language	English
Title of host publication	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages	2663-2666
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2006.259350
Publication status	Published - 1 Dec 2006
Externally published	Yes
Event	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States Duration: 30 Aug 2006 → 3 Sept 2006

Conference

Conference	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Country/Territory	United States
City	New York, NY
Period	30/08/06 → 3/09/06

Keywords

Atherosclerosis
Laguerre expansion technique
Time-resolved fluorescence spectroscopy

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

More information

10.1109/IEMBS.2006.259350

Cite this

Jo, J. A., Fang, Q., Papaioannou, T., Qiao, J. H., Fishbein, M. C., Beseth, B., Dorafshar, A. H., Reil, T., Baker, D., Freischlag, J., Shung, K. K., Sun, L., & Marcu, L. (2006). Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 (pp. 2663-2666). Article 4029431 https://doi.org/10.1109/IEMBS.2006.259350

@inproceedings{793b9312a12e41e68d3320ea6df47476,

title = "Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging",

abstract = "In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.",

keywords = "Atherosclerosis, Laguerre expansion technique, Time-resolved fluorescence spectroscopy",

author = "Jo, {J. A.} and Q. Fang and T. Papaioannou and Qiao, {J. H.} and Fishbein, {M. C.} and B. Beseth and Dorafshar, {A. H.} and T. Reil and D. Baker and J. Freischlag and Shung, {K. K.} and Lei Sun and L. Marcu",

year = "2006",

month = dec,

day = "1",

doi = "10.1109/IEMBS.2006.259350",

language = "English",

isbn = "1424400325",

pages = "2663--2666",

booktitle = "28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06",

note = "28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 ; Conference date: 30-08-2006 Through 03-09-2006",

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Jo, JA, Fang, Q, Papaioannou, T, Qiao, JH, Fishbein, MC, Beseth, B, Dorafshar, AH, Reil, T, Baker, D, Freischlag, J, Shung, KK, Sun, L & Marcu, L 2006, Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. in 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06., 4029431, pp. 2663-2666, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 30/08/06. https://doi.org/10.1109/IEMBS.2006.259350

Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. / Jo, J. A.; Fang, Q.; Papaioannou, T. et al.
28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. 2006. p. 2663-2666 4029431.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

TY - GEN

T1 - Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging

AU - Jo, J. A.

AU - Fang, Q.

AU - Papaioannou, T.

AU - Qiao, J. H.

AU - Fishbein, M. C.

AU - Beseth, B.

AU - Dorafshar, A. H.

AU - Reil, T.

AU - Baker, D.

AU - Freischlag, J.

AU - Shung, K. K.

AU - Sun, Lei

AU - Marcu, L.

PY - 2006/12/1

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N2 - In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.

AB - In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.

KW - Atherosclerosis

KW - Laguerre expansion technique

KW - Time-resolved fluorescence spectroscopy

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U2 - 10.1109/IEMBS.2006.259350

DO - 10.1109/IEMBS.2006.259350

M3 - Conference article published in proceeding or book

C2 - 17946129

SN - 1424400325

SN - 9781424400324

SP - 2663

EP - 2666

BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06

T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06

Y2 - 30 August 2006 through 3 September 2006

ER -

Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging

Abstract

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Keywords

ASJC Scopus subject areas

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