TY - JOUR
T1 - Diagnosis and management of fungal infected optic neuritis
AU - Tan, Shao Ying
AU - Xu, Quan Gang
AU - Wei, Shi Hui
AU - Zhao, Jie
N1 - Publisher Copyright:
Copyright © 2017 by the Editorial Board of OPHTHALMOLOGY IN CHINA.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/5/25
Y1 - 2017/5/25
N2 - Objective: To understand the clinical features, diagnosis and treatment of fungal optic neuritis. Design: Retrospective cases. Participants: Three patients with fungal infected optic neuritis. Methods: The symptoms, signs, imaging examination were evaluated in 3 patients of fungal infected optic neuritis, addition with literature review and summary of the clinical characteristics and key points of diagnosis in this disease. Main Outcome Measures: Clinical symptoms, signs, imaging examinations, pathologic biopsy. Results: Three patients of fungal infected optic neuritis were old aged men, monocular or binocular involved, coexisted with systemic disease. Clinical manifestations included acute severe visual loss, headache, eye pain, eyelid prolapse and eye movement disorders. CT showed soft tissue density and bone resorption in the lateral wall of the orbit. Orbital magnetic resonance (MRI) showed irregular enhancement signal with unclear boundary. Pathological biopsy helped to confirm the fungal hyphae and spores. After surgical lesions removal and long-term systemic anti-fungal treatment, symptoms could be controlled in a stable condition. Conclusion: Fungus infected optic neuritis should be considered when suddenly unilateral visual loss with headache or eye pain. Imaging examination can help for diagnosis and pathological biopsy is the gold standard. Early managements were suggested with surgical removal of the lesions and long-term systemic anti-fungal therapy.
AB - Objective: To understand the clinical features, diagnosis and treatment of fungal optic neuritis. Design: Retrospective cases. Participants: Three patients with fungal infected optic neuritis. Methods: The symptoms, signs, imaging examination were evaluated in 3 patients of fungal infected optic neuritis, addition with literature review and summary of the clinical characteristics and key points of diagnosis in this disease. Main Outcome Measures: Clinical symptoms, signs, imaging examinations, pathologic biopsy. Results: Three patients of fungal infected optic neuritis were old aged men, monocular or binocular involved, coexisted with systemic disease. Clinical manifestations included acute severe visual loss, headache, eye pain, eyelid prolapse and eye movement disorders. CT showed soft tissue density and bone resorption in the lateral wall of the orbit. Orbital magnetic resonance (MRI) showed irregular enhancement signal with unclear boundary. Pathological biopsy helped to confirm the fungal hyphae and spores. After surgical lesions removal and long-term systemic anti-fungal treatment, symptoms could be controlled in a stable condition. Conclusion: Fungus infected optic neuritis should be considered when suddenly unilateral visual loss with headache or eye pain. Imaging examination can help for diagnosis and pathological biopsy is the gold standard. Early managements were suggested with surgical removal of the lesions and long-term systemic anti-fungal therapy.
KW - Fungal infected
KW - Imaging examinations
KW - Optic neuritis
KW - Pathological biopsy
UR - http://www.scopus.com/inward/record.url?scp=85026660210&partnerID=8YFLogxK
U2 - 10.13281/j.cnki.issn.1004-4469.2017.03.012
DO - 10.13281/j.cnki.issn.1004-4469.2017.03.012
M3 - Journal article
AN - SCOPUS:85026660210
SN - 1004-4469
VL - 26
SP - 200
EP - 205
JO - Ophthalmology in China
JF - Ophthalmology in China
IS - 3
ER -