Diabetic nephropathy and endothelial dysfunction: Current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study

Wilson KC Leung, L. Gao, Parco M. Siu, Wai Keung Christopher Lai

Research output: Journal article publicationReview articleAcademic researchpeer-review

41 Citations (Scopus)

Abstract

Functional destruction of endothelium is regarded as an early event that lays the groundwork for the development of renal microangiopathy and subsequent clinical manifestation of nephropathic symptoms. Recent research has shed some light on the molecular mechanisms of type 2 diabetes-associated comorbidity of endothelial dysfunction and nephropathy. Stemming from currently proposed endothelium-centered therapeutic strategies for diabetic nephropathy, this review highlighted some most exploited pathways that involve the intricate coordination of vasodilators, vasoconstrictors and vaso-modulatory molecules in the pathogenesis of diabetic nephropathy. We also emphasized the emerging roles of oxidative and epigenetic modifications of microvasculature as our prospective therapeutics for diabetic renal diseases. Finally, this review in particular addressed the potential use of multispectral optoacoustic tomography in real-time, minimally-invasive vascular imaging of small experimental animals for preclinical renal-kinetic drug trials.
Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalLife Sciences
Volume166
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Diabetic nephropathy
  • Endothelial dysfunction
  • Molecular mechanism
  • Multispectral optoacoustic tomography
  • Therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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