Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P. L. Lam, G. L. Lu, K. M. Hon, K. W. Lee, Cheuk Lam Ho, X. Wang, Cheuk On Tang, K. H. Lam, R. S.M. Wong, S. H.L. Kok, Z. X. Bian, H. Li, K. K.H. Lee, R. Gambari, C. H. Chui, Wai Yeung Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

46 Citations (Scopus)

Abstract

A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1and MBC = 100 μg mL-1). The Ru-C7complex possessed much stronger antibacterial effects than the Ru-C6complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6and Ru-C7complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.
Original languageEnglish
Pages (from-to)3949-3957
Number of pages9
JournalDalton Transactions
Volume43
Issue number10
DOIs
Publication statusPublished - 14 Mar 2014

ASJC Scopus subject areas

  • Inorganic Chemistry

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