Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P. L. Lam; G. L. Lu; K. M. Hon; K. W. Lee; Cheuk Lam Ho; X. Wang; Cheuk On Tang; K. H. Lam; R. S.M. Wong; S. H.L. Kok; Z. X. Bian; H. Li; K. K.H. Lee; R. Gambari; C. H. Chui; Wai Yeung Wong

doi:10.1039/c3dt52879k

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P. L. Lam, G. L. Lu, K. M. Hon, K. W. Lee, Cheuk Lam Ho, X. Wang, Cheuk On Tang, K. H. Lam, R. S.M. Wong, S. H.L. Kok, Z. X. Bian, H. Li, K. K.H. Lee, R. Gambari, C. H. Chui, Wai Yeung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

68 Citations (Scopus)

Abstract

A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1and MBC = 100 μg mL-1). The Ru-C7complex possessed much stronger antibacterial effects than the Ru-C6complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6and Ru-C7complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Original language	English
Pages (from-to)	3949-3957
Number of pages	9
Journal	Dalton Transactions
Volume	43
Issue number	10
DOIs	https://doi.org/10.1039/c3dt52879k
Publication status	Published - 14 Mar 2014

ASJC Scopus subject areas

Inorganic Chemistry

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10.1039/c3dt52879k

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Lam, P. L., Lu, G. L., Hon, K. M., Lee, K. W., Ho, C. L., Wang, X., Tang, C. O., Lam, K. H., Wong, R. S. M., Kok, S. H. L., Bian, Z. X., Li, H., Lee, K. K. H., Gambari, R., Chui, C. H., & Wong, W. Y. (2014). Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus. Dalton Transactions, 43(10), 3949-3957. https://doi.org/10.1039/c3dt52879k

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title = "Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus",

abstract = "A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1and MBC = 100 μg mL-1). The Ru-C7complex possessed much stronger antibacterial effects than the Ru-C6complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6and Ru-C7complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.",

author = "Lam, {P. L.} and Lu, {G. L.} and Hon, {K. M.} and Lee, {K. W.} and Ho, {Cheuk Lam} and X. Wang and Tang, {Cheuk On} and Lam, {K. H.} and Wong, {R. S.M.} and Kok, {S. H.L.} and Bian, {Z. X.} and H. Li and Lee, {K. K.H.} and R. Gambari and Chui, {C. H.} and Wong, {Wai Yeung}",

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doi = "10.1039/c3dt52879k",

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AU - Lam, P. L.

AU - Lu, G. L.

AU - Hon, K. M.

AU - Lee, K. W.

AU - Ho, Cheuk Lam

AU - Wang, X.

AU - Tang, Cheuk On

AU - Lam, K. H.

AU - Wong, R. S.M.

AU - Kok, S. H.L.

AU - Bian, Z. X.

AU - Li, H.

AU - Lee, K. K.H.

AU - Gambari, R.

AU - Chui, C. H.

AU - Wong, Wai Yeung

PY - 2014/3/14

Y1 - 2014/3/14

N2 - A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1and MBC = 100 μg mL-1). The Ru-C7complex possessed much stronger antibacterial effects than the Ru-C6complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6and Ru-C7complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

AB - A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1and MBC = 100 μg mL-1). The Ru-C7complex possessed much stronger antibacterial effects than the Ru-C6complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6and Ru-C7complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

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DO - 10.1039/c3dt52879k

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C2 - 24448670

SN - 1477-9226

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EP - 3957

JO - Dalton Transactions

JF - Dalton Transactions

IS - 10

ER -

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Abstract

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