Development of planar patch clamp technology and its application in the analysis of cellular electrophysiology

Peihua Chen, Wei Zhang, Jun Zhou, Ping Wang, Lidan Xiao, Mo Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)

Abstract

A patch clamp chip, as a novel cell-based chip for electrophysiological recordings, has many prominent advantages such as high resolution, accuracy, high throughput and automation. It can be used to perform multivariate and real-time measurements of cell networks in situ. Therefore, this technology will dramatically promote the research on ionic channels, neuronal networks and the application of this technology in drug screening. This paper reviews the development of planar patch clamp technology and its applications in detail. The latest progress in the research of taste cells electrophysiology and taste transduction is also presented. Finally, this paper analyzes the methodology of neural chips. Based on the current research of our laboratory, the prospective applications of a patch clamp chip in the research of taste sensation and transduction mechanisms at molecular and cellular levels are discussed.
Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalProgress in Natural Science
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • Cellular electrophysiology
  • Patch clamp chip
  • Taste
  • Taste cell
  • Taste transduction

ASJC Scopus subject areas

  • Materials Science(all)

Cite this