Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureus

Pik Ling Lam, Roberto Gambari, Yiu Wan Yip, Marcus Chun Wah Yuen, Kim Hung Lam, Raymond Siu Ming Wong, Xiao Wen Wang, Cheuk On Tang, Stanton Hon Lung Kok, Chung Hin Chui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)

Abstract

Chitosan based microcapsule which encapsulated with phyllanthin was developed by simple coacervation. The composition and surface morphology of phyllanthin containing microcapsules were analyzed by Fourier Transform Infrared spectroscopy and Scanning Electron Microscopy, respectively. The release of phyllanthin from the microcapsules was found to be more than 60% after 120 h. In vitro biological assays demonstrated that these phyllanthin containing microcapsules showed a stronger anti-oxidation potential on both human fibroblasts and keratinocytes as well as a better growth inhibitory activity towards Staphylococcus aureus.
Original languageEnglish
Pages (from-to)468-471
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number1
DOIs
Publication statusPublished - 1 Jan 2012

Keywords

  • Chitosan
  • Human skin cells
  • Microcapsule
  • Phyllanthin
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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