In this article, we report the development of chitosan/miconazole nitrate microcapsules. Four miconazole nitrate ratios including 12.5, 25, 50 and 100mg were performed in the chitosan-based microencapsulation system. Chitosan microcapsules with the drug input of 25mg showed the highest encapsulation efficiency (52.47) and acceptable mean particle size (5.65m) when compared with those of 12.5, 50 and 100mg. Fourier transform infrared spectroscopic spectrum proved the entrapment of miconazole nitrate into chitosan microcapsules. The antifungal result demonstrated that microcapsules containing 75g miconazole nitrate possessed comparable anti-Aspergillus niger activity as the commercial ointment. The growth inhibition of miconazole nitrate containing chitosan microcapsules towards human skin keratinocytes was found to be dose dependent. A total of 75g of miconazole nitrate containing microcapsules revealed about 25 of growth inhibition while that of 150g showed approximately 70 of growth inhibition. Special monitoring should be taken if a higher dose of miconazole nitrate was used to develop the microcapsules.
- cell culture
- controlled release
ASJC Scopus subject areas
- Pharmaceutical Science
- Physical and Theoretical Chemistry
- Organic Chemistry
- Colloid and Surface Chemistry