Development of miconazole nitrate containing chitosan microcapsules and their anti-Aspergillus niger activity

C. W.M. Yuen, Chi Wai Kan, K. L. Cheuk, H. C. Cheung, S. Y. Cheng, Yiu Wan Yip, P. L. Lam

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)


In this article, we report the development of chitosan/miconazole nitrate microcapsules. Four miconazole nitrate ratios including 12.5, 25, 50 and 100mg were performed in the chitosan-based microencapsulation system. Chitosan microcapsules with the drug input of 25mg showed the highest encapsulation efficiency (52.47) and acceptable mean particle size (5.65m) when compared with those of 12.5, 50 and 100mg. Fourier transform infrared spectroscopic spectrum proved the entrapment of miconazole nitrate into chitosan microcapsules. The antifungal result demonstrated that microcapsules containing 75g miconazole nitrate possessed comparable anti-Aspergillus niger activity as the commercial ointment. The growth inhibition of miconazole nitrate containing chitosan microcapsules towards human skin keratinocytes was found to be dose dependent. A total of 75g of miconazole nitrate containing microcapsules revealed about 25 of growth inhibition while that of 150g showed approximately 70 of growth inhibition. Special monitoring should be taken if a higher dose of miconazole nitrate was used to develop the microcapsules.
Original languageEnglish
Pages (from-to)505-510
Number of pages6
JournalJournal of Microencapsulation
Issue number5
Publication statusPublished - 1 Aug 2012


  • cell culture
  • chitosan
  • controlled release
  • microencapsulation

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry


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