Development of calendula oil/chitosan microcapsules and their biological safety evaluation

Pik Ling Lam, Marcus Chun Wah Yuen, Chi Wai Kan, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Kim Hung Lam, Roberto Gambari, Stanton Hon Lung Kok, Chung Hin Chui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

12 Citations (Scopus)

Abstract

Chitosan microcapsules containing calendula oil are prepared by a simple coacervation method. The results show that the performance of the microcapsules, including encapsulation efficiency and particle size, is affected by the change of various processing parameters of microcapsule manufacture. Under the optimal parameter combinations: the chitosan concentration is 1.5% w/v; the core/wall ratio is 0.1gmL-1; the stirring speed is 1200rpm; and the pH value is 10. The compositions and surface morphology of the microcapsules are examined using scanning electron microscope and FTIR spectroscopy. The in vitro cytotoxicity evaluation demonstrates that the microcapsules exhibit no significant cytotoxic effects on human keratinocytes. The in vivo toxicology analysis on mice proves that the microcapsules do not exert any significant necrosis to the liver. It is suggested that our microcapsules could be used as a safe drug carrier both topically and orally. Journal compilation
Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalAustralian Journal of Chemistry
Volume65
Issue number1
DOIs
Publication statusPublished - 16 Feb 2012

ASJC Scopus subject areas

  • Chemistry(all)

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