Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung; Roberto Gambari; Yi Xin Chen; Chor Hing Cheng; Zhao Xiang Bian; Albert Sun Chi Chan; Cheuk On Tang; Hang Mei Polly Leung; Chung Hin Chui; Kim Hung Lam

doi:10.1007/s00044-014-1217-4

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung
, Roberto Gambari
, Yi Xin Chen
, Chor Hing Cheng
, Zhao Xiang Bian
, Albert Sun Chi Chan
, Cheuk On Tang
, Hang Mei Polly Leung
, Chung Hin Chui
, Kim Hung Lam

Research output: Journal article publication › Journal article › Academic research › peer-review

12 Citations (Scopus)

Abstract

A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

Original language	English
Pages (from-to)	1568-1577
Number of pages	10
Journal	Medicinal Chemistry Research
Volume	24
Issue number	4
DOIs	https://doi.org/10.1007/s00044-014-1217-4
Publication status	Published - 1 Jan 2015

Keywords

8-Hydroxyquinoline
A549 cells
Antimicrobial
Aspergillus niger

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

More information

10.1007/s00044-014-1217-4

Cite this

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title = "Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities",

abstract = "A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.",

keywords = "8-Hydroxyquinoline, A549 cells, Antimicrobial, Aspergillus niger",

author = "Chung, \{Po Yee\} and Roberto Gambari and Chen, \{Yi Xin\} and Cheng, \{Chor Hing\} and Bian, \{Zhao Xiang\} and Chan, \{Albert Sun Chi\} and Tang, \{Cheuk On\} and Leung, \{Hang Mei Polly\} and Chui, \{Chung Hin\} and Lam, \{Kim Hung\}",

year = "2015",

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doi = "10.1007/s00044-014-1217-4",

language = "English",

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TY - JOUR

T1 - Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

AU - Chung, Po Yee

AU - Gambari, Roberto

AU - Chen, Yi Xin

AU - Cheng, Chor Hing

AU - Bian, Zhao Xiang

AU - Chan, Albert Sun Chi

AU - Tang, Cheuk On

AU - Leung, Hang Mei Polly

AU - Chui, Chung Hin

AU - Lam, Kim Hung

PY - 2015/1/1

Y1 - 2015/1/1

N2 - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

AB - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

KW - 8-Hydroxyquinoline

KW - A549 cells

KW - Antimicrobial

KW - Aspergillus niger

UR - https://www.scopus.com/pages/publications/84943015111

U2 - 10.1007/s00044-014-1217-4

DO - 10.1007/s00044-014-1217-4

M3 - Journal article

SN - 1054-2523

VL - 24

SP - 1568

EP - 1577

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 4

ER -

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Abstract

Keywords

ASJC Scopus subject areas

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