Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung; Roberto Gambari; Yi Xin Chen; Chor Hing Cheng; Zhao Xiang Bian; Albert Sun Chi Chan; Cheuk On Tang; Hang Mei Polly Leung; Chung Hin Chui; Kim Hung Lam

doi:10.1007/s00044-014-1217-4

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung, Roberto Gambari, Yi Xin Chen, Chor Hing Cheng, Zhao Xiang Bian, Albert Sun Chi Chan, Cheuk On Tang, Hang Mei Polly Leung, Chung Hin Chui, Kim Hung Lam

Research output: Journal article publication › Journal article › Academic research › peer-review

12 Citations (Scopus)

Abstract

A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

Original language	English
Pages (from-to)	1568-1577
Number of pages	10
Journal	Medicinal Chemistry Research
Volume	24
Issue number	4
DOIs	https://doi.org/10.1007/s00044-014-1217-4
Publication status	Published - 1 Jan 2015

Keywords

8-Hydroxyquinoline
A549 cells
Antimicrobial
Aspergillus niger

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

More information

10.1007/s00044-014-1217-4

Cite this

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title = "Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities",

abstract = "A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.",

keywords = "8-Hydroxyquinoline, A549 cells, Antimicrobial, Aspergillus niger",

author = "Chung, {Po Yee} and Roberto Gambari and Chen, {Yi Xin} and Cheng, {Chor Hing} and Bian, {Zhao Xiang} and Chan, {Albert Sun Chi} and Tang, {Cheuk On} and Leung, {Hang Mei Polly} and Chui, {Chung Hin} and Lam, {Kim Hung}",

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doi = "10.1007/s00044-014-1217-4",

language = "English",

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journal = "Medicinal Chemistry Research",

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T1 - Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

AU - Chung, Po Yee

AU - Gambari, Roberto

AU - Chen, Yi Xin

AU - Cheng, Chor Hing

AU - Bian, Zhao Xiang

AU - Chan, Albert Sun Chi

AU - Tang, Cheuk On

AU - Leung, Hang Mei Polly

AU - Chui, Chung Hin

AU - Lam, Kim Hung

PY - 2015/1/1

Y1 - 2015/1/1

N2 - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

AB - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

KW - 8-Hydroxyquinoline

KW - A549 cells

KW - Antimicrobial

KW - Aspergillus niger

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U2 - 10.1007/s00044-014-1217-4

DO - 10.1007/s00044-014-1217-4

M3 - Journal article

SN - 1054-2523

VL - 24

SP - 1568

EP - 1577

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 4

ER -

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Abstract

Keywords

ASJC Scopus subject areas

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