Determination of refractive index for single living cell using integrated biochip

X. J. Liang; A. Q. Liu; Xuming Zhang; P. H. Yap; T. C. Ayi; H. S. Yoon

doi:10.1109/SENSOR.2005.1497421

Determination of refractive index for single living cell using integrated biochip

X. J. Liang, A. Q. Liu, Xuming Zhang, P. H. Yap, T. C. Ayi, H. S. Yoon

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

48 Citations (Scopus)

Abstract

This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.

Original language	English
Title of host publication	TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers
Pages	1712-1715
Number of pages	4
Volume	2
DOIs	https://doi.org/10.1109/SENSOR.2005.1497421
Publication status	Published - 9 Nov 2005
Externally published	Yes
Event	13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05 - Seoul, Korea, Republic of Duration: 5 Jun 2005 → 9 Jun 2005

Conference

Conference	13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Country/Territory	Korea, Republic of
City	Seoul
Period	5/06/05 → 9/06/05

Keywords

External cavity laser
Lab-on-a-chip
Microfluidics
Microlens
Refractive index

ASJC Scopus subject areas

General Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1109/SENSOR.2005.1497421

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Liang, X. J., Liu, A. Q., Zhang, X., Yap, P. H., Ayi, T. C., & Yoon, H. S. (2005). Determination of refractive index for single living cell using integrated biochip. In TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers (Vol. 2, pp. 1712-1715). Article 3E4.104 https://doi.org/10.1109/SENSOR.2005.1497421

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title = "Determination of refractive index for single living cell using integrated biochip",

abstract = "This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.",

keywords = "External cavity laser, Lab-on-a-chip, Microfluidics, Microlens, Refractive index",

author = "Liang, {X. J.} and Liu, {A. Q.} and Xuming Zhang and Yap, {P. H.} and Ayi, {T. C.} and Yoon, {H. S.}",

year = "2005",

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booktitle = "TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers",

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Liang, XJ, Liu, AQ, Zhang, X, Yap, PH, Ayi, TC & Yoon, HS 2005, Determination of refractive index for single living cell using integrated biochip. in TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. vol. 2, 3E4.104, pp. 1712-1715, 13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05, Seoul, Korea, Republic of, 5/06/05. https://doi.org/10.1109/SENSOR.2005.1497421

Determination of refractive index for single living cell using integrated biochip. / Liang, X. J.; Liu, A. Q.; Zhang, Xuming et al.
TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. Vol. 2 2005. p. 1712-1715 3E4.104.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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T1 - Determination of refractive index for single living cell using integrated biochip

AU - Liang, X. J.

AU - Liu, A. Q.

AU - Zhang, Xuming

AU - Yap, P. H.

AU - Ayi, T. C.

AU - Yoon, H. S.

PY - 2005/11/9

Y1 - 2005/11/9

N2 - This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.

AB - This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.

KW - External cavity laser

KW - Lab-on-a-chip

KW - Microfluidics

KW - Microlens

KW - Refractive index

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BT - TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers

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Determination of refractive index for single living cell using integrated biochip

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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