TY - JOUR
T1 - Determinants of the components of arterial pressure among older adults - The role of anthropometric and clinical factors
T2 - A multi-continent study
AU - Tyrovolas, Stefanos
AU - Koyanagi, Ai
AU - Garin, Noe
AU - Olaya, Beatriz
AU - Ayuso-Mateos, Jose Luis
AU - Miret, Marta
AU - Chatterji, Somnath
AU - Tobiasz-Adamczyk, Beata
AU - Koskinen, Seppo
AU - Leonardi, Matilde
AU - Haro, Josep Maria
N1 - Funding Information:
Stefano Tyrovolas received a scholarship from the Foundation for Education and European Culture (IPEP) to undertake his post-doctoral research, of which this work is a part.
Funding Information:
WHO's Study on Global Ageing and Adult Health is supported by the United States National Institute on Aging's Division of Behavioral and Social Research through Interagency Agreements (OGHA 04034785; YA1323-08-CN-0020; Y1-AG- 1005-01) and through research grants (R01-AG034479 and R21-AG034263) and the World Health Organization's Department of Health Statistics and Information Systems. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number 223071 (COURAGE in Europe), from the Instituto de Salud Carlos III-FIS research grants number PS09/00295 and PS09/01845, and from the Spanish Ministry of Science and Innovation ACI-Promociona (ACI2009-1010). The study was also supported by the Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III. The views expressed in this paper are those of the author(s) and do not necessarily represent the views or policies of the World Health Organization. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
Ai Koyanagi's work was supported by the Miguel Servet contract by CIBERSAM.
Publisher Copyright:
© 2014 Elsevier Ireland Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Objective: The aim of this study was to evaluate the factors associated with different components of arterial blood pressure in nine nationally-representative samples of people aged ≥50 years. Methods: Data were available for 53,289 people aged ≥18 years who participated in the SAGE (WHO Study on global AGEing and adult health) study conducted in China, Ghana, India, Mexico, Russia, and South Africa, and the COURAGE (Collaborative Research on Ageing in Europe) study conducted in Finland, Poland, and Spain, between 2007 and 2012. Standard procedures were used to obtain diastolic and systolic blood pressure (DBP, SBP) measurements to identify hypertensive participants, and to determine mean arterial blood pressure (MAP) and pulse pressure (PP). Results: The analytical sample consisted of 42,116 people aged 50 years or older. South Africa had the highest prevalence of hypertension (78.3%), and the highest measurements of MAP±SD (113.6±36.4mmHg), SBP±SD (146.4±49.5mmHg), and DBP±SD (97.2±33.9mmHg). In the adjusted models, dose-dependent positive associations between Body Mass Index (BMI) and MAP or PP were observed in most countries ( p<0.05). Diabetes was positively associated with PP in most countries but the association between diabetes and MAP was less consistent. Stroke was associated with both higher MAP and PP in China, Ghana, and South Africa ( p<0.05). Conclusions: Obesity and diabetes remain important modifiable risk factors for arterial peripheral resistance and stiffness as reflected by MAP and PP respectively. Controlling arterial pressure abnormalities after stroke events may be important for secondary prevention, particularly in developing countries.
AB - Objective: The aim of this study was to evaluate the factors associated with different components of arterial blood pressure in nine nationally-representative samples of people aged ≥50 years. Methods: Data were available for 53,289 people aged ≥18 years who participated in the SAGE (WHO Study on global AGEing and adult health) study conducted in China, Ghana, India, Mexico, Russia, and South Africa, and the COURAGE (Collaborative Research on Ageing in Europe) study conducted in Finland, Poland, and Spain, between 2007 and 2012. Standard procedures were used to obtain diastolic and systolic blood pressure (DBP, SBP) measurements to identify hypertensive participants, and to determine mean arterial blood pressure (MAP) and pulse pressure (PP). Results: The analytical sample consisted of 42,116 people aged 50 years or older. South Africa had the highest prevalence of hypertension (78.3%), and the highest measurements of MAP±SD (113.6±36.4mmHg), SBP±SD (146.4±49.5mmHg), and DBP±SD (97.2±33.9mmHg). In the adjusted models, dose-dependent positive associations between Body Mass Index (BMI) and MAP or PP were observed in most countries ( p<0.05). Diabetes was positively associated with PP in most countries but the association between diabetes and MAP was less consistent. Stroke was associated with both higher MAP and PP in China, Ghana, and South Africa ( p<0.05). Conclusions: Obesity and diabetes remain important modifiable risk factors for arterial peripheral resistance and stiffness as reflected by MAP and PP respectively. Controlling arterial pressure abnormalities after stroke events may be important for secondary prevention, particularly in developing countries.
KW - Developing countries
KW - Hypertension
KW - Mean arterial pressure
KW - Obesity
KW - Pulse pressure
UR - http://www.scopus.com/inward/record.url?scp=84919799310&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2014.11.029
DO - 10.1016/j.atherosclerosis.2014.11.029
M3 - Journal article
C2 - 25528433
AN - SCOPUS:84919799310
SN - 0021-9150
VL - 238
SP - 240
EP - 249
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -