Detection of thyroid abnormalities in aquaporin-4 antibody-seropositive optic neuritis patients

Shuo Zhao, Huanfen Zhou, Xudong Peng, Shaoying Tan, Zihao Liu, Tingjun Chen, Quangang Xu, Shihui Wei

Research output: Journal article publicationJournal articleAcademic researchpeer-review


Objective: This study retrospectively analyzed the frequency of anti-thyroid antibodies (ATAs) and thyroid disease in patients with optic neuritis (ON). Methods: Tests of serum thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies and thyroid function were performed in 97 ON patients. Blood also was drawn to test for AQP4-Ab using cell-based and enzyme-linked immunosorbent assays. Comparisons of the frequencies of ATAs, thyroid diseases and thyroid function were performed based on AQP4-Ab status. Results: Seropositive AQP4-Ab was found in 47/97 (48.5%) patients. ATA was considered positive in 34/97 (35.1%) patients. The prevalence of ATA was two times higher (P = 0.019) in the AQP4-Ab+ group compared to the AQP4-Abgroup. AQP4-Ab+ ON patients exhibited lower FT3 (P = 0.006) and FT4 (P = 0.025) levels and a higher prevalence of definite Hashimoto thyroiditis (HT) (P = 0.005). Among AQP4-Ab+ patients, those with HT had a worse visual outcome than non-HT patients. Conclusion: A high prevalence of ATAs and HT was found in AQP4-Ab+ ON patients, and AQP4-Ab+ patients with HT exhibited worse visual outcomes than non-HT patients.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalJournal of Neuro-Ophthalmology
Issue number1
Publication statusPublished - Mar 2017
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


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