Detection of hifu lesions in excised tissue using acousto-optic imaging

Andrew Draudt, Puxiang Lai, Ronald A. Roy, Todd W. Murray, Robin O. Cleveland

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Real-time imaging of the heating of tissue and lesion formation is a major barrier to the clinical application of HIFU. Tissue necrosis results in a change in the optical properties of the tissue. We have employed the acousto-optical (A-O) interaction to image HIFU lesions formed in excised chicken breast. The tissue was illuminated with infrared light (1064 nm wavelength) resulting in a diffuse optical field throughout the tissue. Simultaneously, the tissue was insonified with a diagnostic ultrasound imager running in B-mode. The photons that passed through the region of tissue where the pulsed 5 MHz ultrasound beam was present were phase modulated by the sound field. These modulated photons were detected by means of an interferometric detector employing a photorefractive crystal (PRC). To first order the amplitude of the output from the PRC is related to the optical absorption of the tissue where the sound was present. By firing multiple acoustic beams along different pathways, the spatially dependent optical absorption coefficient (uncalibrated) within a tissue region of interest is determined and presented in the form of a 2-D image. Images thus generated were recorded in chicken breast before and after HIFU exposure (1.1 MHz, 6 s duration, 6 MPa peak pressure). The acoustic and optical beams were scanned across the tissue, and the waveforms combined to form a 2-D AO image. The imaged lesion size of 9 x 2 mm2agreed well with the measured lesions size 10 x 3 mm2.
Original languageEnglish
Title of host publication8th International Symposium on Therapeutic Ultrasound
Pages270-274
Number of pages5
Volume1113
DOIs
Publication statusPublished - 21 Jul 2009
Externally publishedYes
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: 10 Sep 200813 Sep 2008

Conference

Conference8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period10/09/0813/09/08

Keywords

  • Acousto-Optic Imaging
  • HIFU
  • lesion detection

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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