Detection of early functional changes in diabetic retina using slow double-stimulation mfERG paradigm

Ho Lung Henry Chan, Patrick Ho Wai Chu, Jenny Chun Yee Lung, Wing Cheung Ho, Patrick Wai Ki Ting, Rita Wing Man Sum, Yiu Fai Ng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)

Abstract

Aim: Diabetes mellitus (DM) is a systemic disease with insufficient secretion of insulin or poor response to insulin. This typically causes poor control of blood glucose level leading to a range of complications. Early detection of the retinal function alteration in DM is needed. Methods: A newly modified paradigm - slow double-stimulation multifocal electroretinogram (mfERG) - was introduced to measure early changes of retinal function in DM and to investigate changes in the adaptation mechanisms in the diabetic retina. The mfERG was measured by using a slow double-stimulation mfERG paradigm (M 1M 2OOO). Results: The m1 amplitude of M 1 stimulation from diabetic subjects was significantly reduced in ring 1 in contrast to that of a control group. The m2 amplitude of M 2 stimulation from diabetic subjects was also significantly reduced in ring 1 and 2 as compared with those of the control group. The m1/m2 ratio which minimises intersubject variation shows a reasonable differentiation between the control and diabetic groups. There was a significant increase in the amplitude ratio from diabetic subjects in ring 2 and 3 as compared with those of the control group. Conclusions: The present findings suggest that the new mfERG paradigm is a fast and sensitive test for the detection of early functional changes in the diabetic retina.
Original languageEnglish
Pages (from-to)1560-1563
Number of pages4
JournalBritish Journal of Ophthalmology
Volume95
Issue number11
DOIs
Publication statusPublished - 1 Nov 2011

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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