Detection of cancer biomarkers by piezoelectric biosensor using PZT ceramic resonator as the transducer

Li Su, Lan Zou, Chi Chun Fong, Wing Leung Wong, Fan Wei, Kwok Yin Wong, Rudolf S.S. Wu, Mengsu Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

45 Citations (Scopus)

Abstract

A novel piezoelectric biosensor using lead titanate zirconate (PZT) ceramic resonator as transducer was developed for label-free, cost-effective, and direct detection of cancer biomarkers. We designed a dual sensing scheme where two ceramic resonators were connected in parallel, in which one resonator was used as the sensing unit and the other as the control unit, in order to minimize environment influences including temperature fluctuation and to achieve the required frequency stability for biosensing applications. Detection of selected cancer biomarkers, such as prostate specific antigen (PSA) and α-fetoprotein (AFP) was carried out to evaluate the performance of the biosensor. The device showed high sensitivity (0.25. ng/ml) and fast detection (within 30. min) with small amount of sample (1 μl), which is compatible to that required by clinical measurements. The results also showed that the ceramic resonator-based piezoelectric biosensor platform could be utilized with different chemical interfaces, and the miniaturized size of the ceramic resonators makes it suitable for fabricating sensor arrays for multiplex detection.
Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalBiosensors and Bioelectronics
Volume46
DOIs
Publication statusPublished - 5 Aug 2013

Keywords

  • Cancer marker detection
  • Dual ceramic resonator
  • Piezoelectric biosensor
  • Resonance frequency

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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