Detection of Bisphenol A Using DNA-Functionalized Graphene Field Effect Transistors Integrated in Microfluidic Systems

Shenghua Liu, Ying Fu, Can Xiong, Zhike Liu, Lei Zheng, Feng Yan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)


Bisphenol A (BPA) detection has attracted much attention recently for its importance to food safety and environment. The DNA-functionalized solution-gated graphene transistors are integrated in microfluidic systems and used for recycling detections of BPA for the first time. In the presence of BPA, both single- and double-stranded DNA molecules are detached and released from the graphene surface in aqueous solutions, leading to the change of device electrical performance. The channel currents of the devices change monotonically with the concentration of BPA. Moreover, the devices modified with double-stranded DNA are more sensitive to BPA and show the detection limit down to 10 ng/mL. The highly sensitive label-free BPA sensors are expected to be used for convenient BPA detections in many applications.

Original languageEnglish
Pages (from-to)23522-23528
Number of pages7
JournalACS Applied Materials and Interfaces
Issue number28
Publication statusPublished - 18 Jul 2018


  • biosensor
  • bisphenol A detection
  • DNA aptamer
  • graphene
  • solution-gated graphene transistor

ASJC Scopus subject areas

  • Materials Science(all)

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