Abstract
G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.
| Original language | English |
|---|---|
| Pages (from-to) | 1163-1178 |
| Number of pages | 16 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 8 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 10 Dec 2008 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Affinity and selectivity
- DNA interactions
- G-quadruplex
- G-quartet
- Ligands
- Substituted derivatives
- Telomerase inhibition
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
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