Design of selective G-quadruplex ligands as potential anticancer agents

Jia Heng Tan, Lian Quan Gu, Jianyong Wu

Research output: Journal article publicationReview articleAcademic researchpeer-review

67 Citations (Scopus)


G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.
Original languageEnglish
Pages (from-to)1163-1178
Number of pages16
JournalMini-Reviews in Medicinal Chemistry
Issue number11
Publication statusPublished - 10 Dec 2008


  • Affinity and selectivity
  • DNA interactions
  • G-quadruplex
  • G-quartet
  • Ligands
  • Substituted derivatives
  • Telomerase inhibition

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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