Design of selective G-quadruplex ligands as potential anticancer agents

Jia Heng Tan; Lian Quan Gu; Jianyong Wu

doi:10.2174/138955708785909880

Design of selective G-quadruplex ligands as potential anticancer agents

Jia Heng Tan, Lian Quan Gu, Jianyong Wu

Research output: Journal article publication › Review article › Academic research › peer-review

71 Citations (Scopus)

Abstract

G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.

Original language	English
Pages (from-to)	1163-1178
Number of pages	16
Journal	Mini-Reviews in Medicinal Chemistry
Volume	8
Issue number	11
DOIs	https://doi.org/10.2174/138955708785909880
Publication status	Published - 10 Dec 2008

Keywords

Affinity and selectivity
DNA interactions
G-quadruplex
G-quartet
Ligands
Substituted derivatives
Telomerase inhibition

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.2174/138955708785909880

Cite this

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keywords = "Affinity and selectivity, DNA interactions, G-quadruplex, G-quartet, Ligands, Substituted derivatives, Telomerase inhibition",

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AU - Gu, Lian Quan

AU - Wu, Jianyong

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KW - G-quartet

KW - Ligands

KW - Substituted derivatives

KW - Telomerase inhibition

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Design of selective G-quadruplex ligands as potential anticancer agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

More information

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