Design of an Indolylphosphine Ligand for Reductive Elimination-Demanding Monoarylation of Acetone Using Aryl Chlorides

Wai Chung Fu, Chau Ming So, Wing Kin Chow, On Ying Yuen, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

46 Citations (Scopus)


The rational design of a phosphine ligand for the reductive elimination-demanding Pd-catalyzed mono-α-arylation of acetone is demonstrated and reported. The catalyst is tolerant of previously proven challenging electron-deficient aryl chlorides and provides excellent product yields with down to 0.1 mol % Pd. Preliminary investigations suggest that the rate-limiting step for the proposed system is the oxidative addition of aryl chlorides, in which it contradicts previous findings regarding the α-arylation of acetone with aryl halides.
Original languageEnglish
Pages (from-to)4612-4615
Number of pages4
JournalOrganic Letters
Issue number18
Publication statusPublished - 18 Sep 2015

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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