Abstract
Deep tissue injuries (DTI) involve damages in the subcutaneous tissues under intact skin incurred by prolonged excessive epidermal loadings. This paper presents a new theoretical model for the development of DTI, broadly based on the experimental evidence in the literatures. The model covers the loading damages implicitly inclusive of both the direct mechanical and ischemic injuries, and the additional reperfusion damages and the competing healing processes during the unloading phase. Given the damage accumulated at the end of the loading period, the relative strength of the reperfusion and the healing capacity of the involved tissues system, the model provides a description of the subsequent damage evolution during unloading. The model is used to study parametrically the scenario when reperfusion damage dominates over healing upon unloading and the opposite scenario when the loading and subsequent reperfusion damages remain small relative to the healing capacity of the tissues system. The theoretical model provides an integrated understanding of how tissue damage may further build-up paradoxically even with unloading, how long it would take for the loading and reperfusion damages in the tissues to become fully recovered, and how such loading and reperfusion damages, if not given sufficient time for recovery, may accumulate over multiple loading and unloading cycles, leading to clinical deep tissues ulceration.
Original language | English |
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Pages (from-to) | 65-73 |
Number of pages | 9 |
Journal | Journal of Theoretical Biology |
Volume | 289 |
Issue number | 1 |
DOIs | |
Publication status | Published - 21 Nov 2011 |
Keywords
- Biomechanics
- Damage accumulation
- Ischemia
- Pressure ulcer
- Reperfusion
ASJC Scopus subject areas
- Statistics and Probability
- General Medicine
- Modelling and Simulation
- General Immunology and Microbiology
- General Biochemistry,Genetics and Molecular Biology
- General Agricultural and Biological Sciences
- Applied Mathematics