Deep Phenotyping Post-Stroke Recovery: A Holistic Approach for Occupational Therapy

Introduction: Stroke rehabilitation primarily focuses on restoring motor function, with occupational therapists emphasizing upper limb motor relearning. However, recovery is not a linear or isolated process, it is shaped by various dimensions, including time, mental health, cognition, social support, spirituality, and rehabilitation progress. Understanding these factors is crucial to fully supporting stroke survivors.

Objective: This study aims to deeply phenotype the recovery process of 30 stroke survivors from stroke onset over a two-year period, uncovering the key determinants that influence post-stroke recovery.

Methods: This longitudinal mixed-methods study includes three major assessment points at 6, 12, and 24 months post-stroke. Standardized quantitative assessments measure motor, cognitive, social, occupational balance, and mental health outcomes. Complementing this, semi-structured interviews explore participants’ evolving perceptions of identity, impairments, and the rehabilitation journey, as well as their views on mental health, spirituality, and social support. Additionally, participants wore a Fitbit Inspire 3 for 12 months, providing real-world data on sleep patterns, activity levels, and lifestyle factors.

Results: This presentation will share preliminary findings from both quantitative and qualitative analyses, shedding light on the intricate psychosocial factors that shape upper limb recovery. Deep phenotyping offers occupational therapists a broader lens to understand stroke rehabilitation, opening opportunities to design interventions that extend beyond motor function and truly support holistic recovery.

Contribution to the occupational therapy profession: Deep phenotyping in post-stroke rehabilitation presents a crucial opportunity for occupational therapists to refine and personalize rehabilitation programs. By capturing the multidimensional nature of recovery, this approach enables us to develop interventions that align with each patient’s unique journey.