Data on differentially expressed proteins in retinal emmetropization process in guinea pig using integrated SWATH-based and targeted-based proteomics

Sze Wan Shan, Dennis Yan yin Tse, Bing Zuo, Chi ho To, Quan Liu, Sally A. McFadden, Rachel Ka Man Chun, Jingfang Bian, King Kit Li, Thomas Chuen Lam

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)

Abstract

Myopia is generally regarded as a failure of normal emmetropization process, however, its underlying molecular mechanisms are unclear. Retinal protein profile changes using integrated SWATH and MRM-HR MS were studied in guinea pigs at 3- and 21-days of age, where the axial elongation was significantly detected. Differential proteins expressions were identified, and related to pathways which are important in postnatal development in retina, proliferation, breakdown of glycogen-energy and visual phototransduction. These results are significant as key retinal protein players and pathways that underlying emmetropization can be discovered. All raw data generated from IDA and SWATH acquisitions were accepted and published in the Peptide Atlas public repository (http://www.peptideatlas.org/) for general release (Data ID PASS00746). A more comprehensive analysis of this data can be obtained in the article “Integrated SWATH-based and targeted-based proteomics provide insights into the retinal emmetropization process in guinea pig” in Journal of Proteomics (Shan et al., 2018) [1].

Original languageEnglish
Pages (from-to)1750-1755
Number of pages6
JournalData in Brief
Volume21
Early online date31 Aug 2018
DOIs
Publication statusPublished - Dec 2018

ASJC Scopus subject areas

  • General

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