Cumulative effects of hypertension, dyslipidemia, and chronic kidney disease on carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus

Chuang Yuan, Wai Keung Christopher Lai, Wing Chi Chan, Meyrick Chow, Ka Wai Helen Law, Tin Cheung Ying

Research output: Journal article publicationJournal articleAcademic researchpeer-review

19 Citations (Scopus)

Abstract

Aims. The aim of this study is to determine the extent of carotid atherosclerosis in Chinese patients with type 2 diabetes in relation to the cumulative atherosclerosis risk factors using ultrasonography. Methods. The presence of hypertension, dyslipidemia, and chronic kidney disease (CKD) was documented in 106 Chinese subjects with type 2 diabetes. Subjects with 0, 1, and ≥2 additional atherosclerosis risk factors were assigned into groups 1, 2, and 3, respectively (n = 17, 49, and 40, resp.). Using ultrasound, the carotid arteries were assessed for the presence of carotid plaque, plaque score, intima-media thickness (IMT), and carotid arterial stiffness. Results. With the adjustment for age and gender, the presence of plaque and plaque score were significantly higher in groups with more atherosclerosis risk factors (P < 0.05). In addition, age > 60 years old (odds ratio = 2.75; 95% CI: 1.26-6.0) and the presence of hypertension (odds ratio = 2.48; 95% CI: 1.11-5.58), dyslipidemia (odds ratio = 2.41; 95% CI: 1.05-5.51), and CKD (odds ratio = 7.80; 95% CI: 1.46-41.72) could independently predict higher plaque score (P < 0.05). Conclusions. Hypertension, dyslipidemia, and CKD in Chinese patients with type 2 diabetes have cumulative effects on the burden of carotid plaque.
Original languageEnglish
Article number179686
JournalJournal of Diabetes Research
Volume2014
DOIs
Publication statusPublished - 1 Jan 2014

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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