Cross-talk between adipose tissue and vasculature: Role of adiponectin

F. Y L Li, King Yip Cheng, K. S L Lam, P. M. Vanhoutte, A. Xu

Research output: Journal article publicationReview articleAcademic researchpeer-review

101 Citations (Scopus)

Abstract

Adipose tissue is a highly dynamic endocrine organ, secreting a number of bioactive substances (adipokines) regulating insulin sensitivity, energy metabolism and vascular homeostasis. Dysfunctional adipose tissue is a key mediator that links obesity with insulin resistance, hypertension and cardiovascular disease. Obese adipose tissue is characterized by adipocyte hypertrophy and infiltration of inflammatory macrophages and lymphocytes, leading to the augmented production of pro-inflammatory adipokines and vasoconstrictors that induce endothelial dysfunction and vascular inflammation through their paracrine and endocrine actions. By contrast, the secretion of adiponectin, an adipokine with insulin sensitizing and anti-inflammatory activities, is decreased in obesity and its related pathologies. Emerging evidence suggests that adiponectin is protective against vascular dysfunction induced by obesity and diabetes, through its multiple favourable effects on glucose and lipid metabolism as well as on vascular function. Adiponectin improves insulin sensitivity and metabolic profiles, thus reducing the classical risk factors for cardiovascular disease. Furthermore, adiponectin protects the vasculature through its pleiotropic actions on endothelial cells, endothelial progenitor cells, smooth muscle cells and macrophages. Data from both animal and human investigations demonstrate that adiponectin is an important component of the adipo-vascular axis that mediates the cross-talk between adipose tissue and vasculature. This review highlights recent work on the vascular protective activities of adiponectin and discusses the molecular pathways underlying the vascular actions of this adipokine. Acta Physiologica
Original languageEnglish
Pages (from-to)167-180
Number of pages14
JournalActa Physiologica
Volume203
Issue number1
DOIs
Publication statusPublished - 1 Sep 2011
Externally publishedYes

Keywords

  • Adipokine
  • Endothelial function
  • Inflammation
  • Obesity
  • Vascular homeostasis

ASJC Scopus subject areas

  • Physiology

Cite this