[Cp*RhCl2]2-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines

Ka Ho Ng; Zhongyuan Zhou; Wing Yiu Yu

doi:10.1039/c3cc42937g

[Cp*RhCl₂]₂-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines

Ka Ho Ng, Zhongyuan Zhou, Wing Yiu Yu

Research output: Journal article publication › Journal article › Academic research › peer-review

76 Citations (Scopus)

Abstract

Rh(iii)-catalyzed aromatic C-H amination of acetophenone o-methyloximes with primary N-chloroalkylamines was developed, and the arylamine products were obtained in up to 92% yield. The reaction probably involves rate-limiting electrophilic C-H bond cleavage (kH/kD= 2).

Original language	English
Pages (from-to)	7031-7033
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	63
DOIs	https://doi.org/10.1039/c3cc42937g
Publication status	Published - 14 Aug 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc42937g

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title = "[Cp*RhCl2]2-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines",

abstract = "Rh(iii)-catalyzed aromatic C-H amination of acetophenone o-methyloximes with primary N-chloroalkylamines was developed, and the arylamine products were obtained in up to 92% yield. The reaction probably involves rate-limiting electrophilic C-H bond cleavage (kH/kD= 2).",

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[Cp*RhCl₂]₂-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines. / Ng, Ka Ho; Zhou, Zhongyuan; Yu, Wing Yiu.
In: Chemical Communications, Vol. 49, No. 63, 14.08.2013, p. 7031-7033.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

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AU - Zhou, Zhongyuan

AU - Yu, Wing Yiu

PY - 2013/8/14

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N2 - Rh(iii)-catalyzed aromatic C-H amination of acetophenone o-methyloximes with primary N-chloroalkylamines was developed, and the arylamine products were obtained in up to 92% yield. The reaction probably involves rate-limiting electrophilic C-H bond cleavage (kH/kD= 2).

AB - Rh(iii)-catalyzed aromatic C-H amination of acetophenone o-methyloximes with primary N-chloroalkylamines was developed, and the arylamine products were obtained in up to 92% yield. The reaction probably involves rate-limiting electrophilic C-H bond cleavage (kH/kD= 2).

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U2 - 10.1039/c3cc42937g

DO - 10.1039/c3cc42937g

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VL - 49

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JO - Chemical Communications

JF - Chemical Communications

IS - 63

ER -

[Cp*RhCl₂]₂-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines

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