Coupling and coordination in gene expression processes with pre-mRNA splicing

Kewu Pan, Jimmy Tsz Hang Lee, Zhe Huang, Chi Ming Wong

Research output: Journal article publicationReview articleAcademic researchpeer-review

5 Citations (Scopus)


RNA processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation. It has been well-documented that splicing of RNA polymerase II medicated nascent transcripts occurs co-transcriptionally and is functionally coupled to other RNA processing. Recently, increasing experimental evidence indicated that pre-mRNA splicing influences RNA degradation and vice versa. In this review, we summarized the recent findings demonstrating the coupling of these two processes. In addition, we highlighted the importance of splicing in the production of intronic miRNA and circular RNAs, and hence the discovery of the novel mechanisms in the regulation of gene expression.
Original languageEnglish
Pages (from-to)5682-5696
Number of pages15
JournalInternational Journal of Molecular Sciences
Issue number3
Publication statusPublished - 11 Mar 2015
Externally publishedYes


  • Circular RNA
  • Exosome
  • MicroRNA processing
  • Mirtron
  • Pre-mRNA splicing
  • RNA surveillance

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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