Cosmetic and skincare benefits of cultivated mycelia from the chinese caterpillar mushroom, ophiocordyceps sinensis (Ascomycetes)

Wai Yin Cheng, Xue Qin Wei, Ka Chai Siu, Ang Xin Song, Jian Yong Wu (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)


Mushrooms are potential sources of novel natural cosmeceutical ingredients. This study was conducted to evaluate the cosmetic (skincare) benefits of the valuable medicinal species Ophiocordyceps sinensis (=Cordyceps sinensis). The mycelial extracts of 2 O. sinensis strains, Cs-HK1 and Cs-4, prepared sequentially with ethyl acetate, ethanol, and hot water were tested with in vitro assays for tyrosinase-, collagenase-, and elastase-inhibitory activity. The ethyl acetate extracts of both fungal strains showed potent antityrosinase and antielastase activity, with low half-maximal inhibitory concentrations (0.14–0.47 mg/mL) comparable to those of the respective reference compounds (arbutin and epigallocatechin gallate). All mycelial extracts exhibited moderate or significant anticollagenase activity; most extracts showed a significant photoprotective effect with a sun protection factor up to 25. The results from this study show the potential use of O. sinensis as a source of cosmetic ingredients for skincare applications.

Original languageEnglish
Pages (from-to)623-636
Number of pages14
JournalInternational Journal of Medicinal Mushrooms
Issue number7
Publication statusPublished - 1 Jan 2018


  • Anticollagenase
  • Antielastase
  • Antioxidant
  • Antityrosinase
  • Cordyceps sinensis
  • Medicinal mushrooms and fungi
  • Mycelial extract
  • Ophiocordyceps sinensis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

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