Abstract
The first catalytic asymmetric addition of terminal alkynes to β-imino esters was carried out using chiral copper(I) complexes as catalysts under mild reaction conditions, providing an efficient and direct synthetic approach to β3-alkynyl β2,2-dimethyl amino esters with yields of 73-97% and 48-90% ee. The rich chemistry of the alkynyl functionality makes the present method a powerful and versatile approach to a wide range of optically active β2,2-dimethyl amino acid derivatives. KGaA.
Original language | English |
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Pages (from-to) | 1250-1254 |
Number of pages | 5 |
Journal | Advanced Synthesis and Catalysis |
Volume | 351 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Jun 2009 |
Keywords
- β-imino esters
- Asymmetric alkynylation
- Asymmetric catalysis
- Copper
- Enantioselectivity
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry