Copper-Catalyzed Synthesis of Functionalized Aryl Sulfonamides from Sodium Sulfinates in Green Solvents

Long Yin Lam, King Hong Chan, Cong Ma (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Functionalized aryl sulfonamides are important building blocks in the pharmaceutical industry. A one-step synthesis catalyzed by a copper salt was developed using stable solid commodity chemicals in sulfolane or, alternatively, in green solvents such as γ-valerolactone, iPrOAc, or nBuOAc with acetic acid. The method tolerated diverse functional groups commonly presented in current medicines and drug intermediates. The mechanistic study showed a radical coupling pathway between the sulfonyl and anilinium radicals through the use of K2S2O8 and copper catalyst, respectively.
Original languageEnglish
Pages (from-to)8802-8810
JournalJournal of Organic Chemistry
Volume87
Issue number13
DOIs
Publication statusPublished - 19 Jun 2022

Fingerprint

Dive into the research topics of 'Copper-Catalyzed Synthesis of Functionalized Aryl Sulfonamides from Sodium Sulfinates in Green Solvents'. Together they form a unique fingerprint.

Cite this