Copper-Catalyzed Oxidative C-H Amination of Tetrahydrofuran with Indole/Carbazole Derivatives

Qingjing Yang, Pui Ying Choy, Wai Chung Fu, Baomin Fan, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

60 Citations (Scopus)

Abstract

A simple α-C-H amination of cyclic ether with indole/carbazole derivatives has been accomplished by employing copper(II) chloride/bipy as the catalyst system. In the presence of the di-tert-butyl peroxide oxidant, cyclic ethers such as tetrahydrofuran, 1,4-dioxane, and tetrahydropyran successfully undergo C-H/N-H cross dehydrogenative coupling (CDC) with various carbazole or indole derivatives in good-to-excellent yields.

Original languageEnglish
Pages (from-to)11193-11199
Number of pages7
JournalJournal of Organic Chemistry
Volume80
Issue number21
DOIs
Publication statusPublished - 6 Nov 2015

ASJC Scopus subject areas

  • Organic Chemistry

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