Copper-catalyzed cross-dehydrogenative coupling of N-arylacrylamides with chloroform using tert-butyl peroxybenzoate as oxidant for the synthesis of trichloromethylated 2-oxindoles

Chun Wo Chan, Pui Yiu Lee, Wing Yiu Yu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

A Cu-catalyzed cross-dehydrogenative coupling of N-arylacrylamides with chloroform is achieved using tert-butyl peroxybenzoate as oxidant, and trichloromethylated oxindoles were obtained in excellent yield and regioselectivity. This reaction should proceed by cascade CCl3radical CC addition and aryl cyclization.
Original languageEnglish
Pages (from-to)2559-2563
Number of pages5
JournalTetrahedron Letters
Volume56
Issue number20
DOIs
Publication statusPublished - 13 May 2015

Keywords

  • 2-Oxindole
  • CH activation
  • Cross-dehydrogenative coupling
  • Cyclization

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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