Copper-catalysed synthesis of oxadiazole and triazine derivatives from aldoximes and amidines

Guozhang Fu; Zhuoqun Hou; Jiaxin Liang; Shasha Wang; Haoxian Wu; Tsz Woon Benedict Lo; Zhongzhi Zhu; Xiuwen Chen

doi:10.1016/j.molstruc.2025.143300

Copper-catalysed synthesis of oxadiazole and triazine derivatives from aldoximes and amidines

Guozhang Fu
, Zhuoqun Hou
, Jiaxin Liang
, Shasha Wang
, Haoxian Wu
, Tsz Woon Benedict Lo
, Zhongzhi Zhu
, Xiuwen Chen

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

Herein, we develop a method for synthesising 1,2,4-oxadiazole derivatives via the [3 + 2] cyclisation of aldoximes with amidines. Using different types of copper catalysts and temperature modulation are crucial for the selective production of 1,2,4-oxadiazole or 1,3,5-triazine derivatives. This method requires readily available materials and offers operational simplicity, a broad substrate scope and environmental friendliness, with gram-scale experiments confirming its applicability.

Original language	English
Article number	143300
Journal	Journal of Molecular Structure
Volume	1347
DOIs	https://doi.org/10.1016/j.molstruc.2025.143300
Publication status	Published - 12 Jul 2025

Keywords

Copper catalysis
Cyclisation
Oxadiazole
Triazine

ASJC Scopus subject areas

Analytical Chemistry
Spectroscopy
Organic Chemistry
Inorganic Chemistry

More information

10.1016/j.molstruc.2025.143300

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title = "Copper-catalysed synthesis of oxadiazole and triazine derivatives from aldoximes and amidines",

abstract = "Herein, we develop a method for synthesising 1,2,4-oxadiazole derivatives via the [3 + 2] cyclisation of aldoximes with amidines. Using different types of copper catalysts and temperature modulation are crucial for the selective production of 1,2,4-oxadiazole or 1,3,5-triazine derivatives. This method requires readily available materials and offers operational simplicity, a broad substrate scope and environmental friendliness, with gram-scale experiments confirming its applicability.",

keywords = "Copper catalysis, Cyclisation, Oxadiazole, Triazine",

author = "Guozhang Fu and Zhuoqun Hou and Jiaxin Liang and Shasha Wang and Haoxian Wu and Lo, \{Tsz Woon Benedict\} and Zhongzhi Zhu and Xiuwen Chen",

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doi = "10.1016/j.molstruc.2025.143300",

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T1 - Copper-catalysed synthesis of oxadiazole and triazine derivatives from aldoximes and amidines

AU - Fu, Guozhang

AU - Hou, Zhuoqun

AU - Liang, Jiaxin

AU - Wang, Shasha

AU - Wu, Haoxian

AU - Lo, Tsz Woon Benedict

AU - Zhu, Zhongzhi

AU - Chen, Xiuwen

PY - 2025/7/12

Y1 - 2025/7/12

N2 - Herein, we develop a method for synthesising 1,2,4-oxadiazole derivatives via the [3 + 2] cyclisation of aldoximes with amidines. Using different types of copper catalysts and temperature modulation are crucial for the selective production of 1,2,4-oxadiazole or 1,3,5-triazine derivatives. This method requires readily available materials and offers operational simplicity, a broad substrate scope and environmental friendliness, with gram-scale experiments confirming its applicability.

AB - Herein, we develop a method for synthesising 1,2,4-oxadiazole derivatives via the [3 + 2] cyclisation of aldoximes with amidines. Using different types of copper catalysts and temperature modulation are crucial for the selective production of 1,2,4-oxadiazole or 1,3,5-triazine derivatives. This method requires readily available materials and offers operational simplicity, a broad substrate scope and environmental friendliness, with gram-scale experiments confirming its applicability.

KW - Copper catalysis

KW - Cyclisation

KW - Oxadiazole

KW - Triazine

UR - https://www.scopus.com/pages/publications/105010958838

U2 - 10.1016/j.molstruc.2025.143300

DO - 10.1016/j.molstruc.2025.143300

M3 - Journal article

AN - SCOPUS:105010958838

SN - 0022-2860

VL - 1347

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 143300

ER -

Copper-catalysed synthesis of oxadiazole and triazine derivatives from aldoximes and amidines

Abstract

Keywords

ASJC Scopus subject areas

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