Controlled Cell Patterning on Bioactive Surfaces with Special Wettability

Xiaofeng Zhou, Jiaqian Li, Hongyan Sun, Yi Hu, Lufeng Che, Zuankai Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

12 Citations (Scopus)


The ability to control cell patterning on artificial substrates with various physicochemical properties is of essence for important implications in cytology and biomedical fields. Despite extensive progress, the ability to control the cell-surface interaction is complicated by the complexity in the physiochemical features of bioactive surfaces. In particular, the manifestation of special wettability rendered by the combination of surface roughness and surface chemistry further enriches the cell-surface interaction. Herein we investigated the cell adhesion behaviors of Circulating Tumor Cells (CTCs) on topographically patterned but chemically homogeneous surfaces. Harnessing the distinctive cell adhesion on surfaces with different topography, we further explored the feasibility of controlled cell patterning using periodic lattices of alternative topographies. We envision that our method provides a designer's toolbox to manage the extracellular environment.

Original languageEnglish
Pages (from-to)440-447
Number of pages8
JournalJournal of Bionic Engineering
Issue number3
Publication statusPublished - Jul 2017
Externally publishedYes


  • cell patterning
  • circulating tumor cells
  • superhydrophilic
  • surface chemistry
  • wettability

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering


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