TY - JOUR
T1 - Contrasting Roles for Orbitofrontal Cortex and Amygdala in Credit Assignment and Learning in Macaques
AU - Chau, Ka Hung Bolton
AU - Sallet, Jérôme
AU - Papageorgiou, Georgios K.
AU - Noonan, Mary Ann P
AU - Bell, Andrew H.
AU - Walton, Mark E.
AU - Rushworth, Matthew F S
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Recent studies have challenged the view that orbitofrontal cortex (OFC) and amygdala mediate flexible reward-guided behavior. We trained macaques to perform an object discrimination reversal task during fMRI sessions and identified a lateral OFC (lOFC) region in which activity predicted adaptive win-stay/lose-shift behavior. Amygdala and lOFC activity was more strongly coupled on lose-shift trials. However, lOFC-amygdala coupling was also modulated by the relevance of reward information in a manner consistent with a role in establishing how credit for reward should be assigned. Day-to-day fluctuations in signals and signal coupling were correlated with day-to-day fluctuation in performance. A second experiment confirmed the existence of signals for adaptive stay/shift behavior in lOFC and reflecting irrelevant reward in the amygdala in a probabilistic learning task. Our data demonstrate that OFC and amygdala each make unique contributions to flexible behavior and credit assignment.
AB - Recent studies have challenged the view that orbitofrontal cortex (OFC) and amygdala mediate flexible reward-guided behavior. We trained macaques to perform an object discrimination reversal task during fMRI sessions and identified a lateral OFC (lOFC) region in which activity predicted adaptive win-stay/lose-shift behavior. Amygdala and lOFC activity was more strongly coupled on lose-shift trials. However, lOFC-amygdala coupling was also modulated by the relevance of reward information in a manner consistent with a role in establishing how credit for reward should be assigned. Day-to-day fluctuations in signals and signal coupling were correlated with day-to-day fluctuation in performance. A second experiment confirmed the existence of signals for adaptive stay/shift behavior in lOFC and reflecting irrelevant reward in the amygdala in a probabilistic learning task. Our data demonstrate that OFC and amygdala each make unique contributions to flexible behavior and credit assignment.
UR - http://www.scopus.com/inward/record.url?scp=84940543051&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2015.08.018
DO - 10.1016/j.neuron.2015.08.018
M3 - Journal article
C2 - 26335649
SN - 0896-6273
VL - 87
SP - 1106
EP - 1118
JO - Neuron
JF - Neuron
IS - 5
ER -