Construction and characterization of nanosized curdlan sulfate/chitosan polyelectrolyte complex toward drug release of zidovudine

Jing Kun Yan, Yao Yao Wang, Wen Yi Qiu, Jianyong Wu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)

Abstract

Nanosized PECs were formed simply by mixing CRDS (0.5 mg/mL) and CS (0.5 mg/mL) at a mass ratio of 2:1 at pH 3.5. The CRDS/CS PECs exhibited a spherical morphology with a Z-average diameter of around 180 nm and a zeta potential value of about −38 mV. Subsequently, zidovudine (AZT) as a model antiviral drug was successfully encapsulated into the nanosized PECs with a favorable drug loading efficiency. The AZT-loaded PECs presented a controlled and pH-dependent AZT release profile. These findings suggest that the CRDS/CS PECs constructed in the present study can be developed as potential nanocarriers for drug delivery applications.
Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalCarbohydrate Polymers
Volume174
DOIs
Publication statusPublished - 15 Oct 2017

Keywords

  • Chitosan
  • Curdlan sulfate
  • Drug delivery
  • Nanocarrier
  • Polyelectrolyte complex
  • Zidovudine

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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