Abstract
Nanosized PECs were formed simply by mixing CRDS (0.5 mg/mL) and CS (0.5 mg/mL) at a mass ratio of 2:1 at pH 3.5. The CRDS/CS PECs exhibited a spherical morphology with a Z-average diameter of around 180 nm and a zeta potential value of about −38 mV. Subsequently, zidovudine (AZT) as a model antiviral drug was successfully encapsulated into the nanosized PECs with a favorable drug loading efficiency. The AZT-loaded PECs presented a controlled and pH-dependent AZT release profile. These findings suggest that the CRDS/CS PECs constructed in the present study can be developed as potential nanocarriers for drug delivery applications.
Original language | English |
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Pages (from-to) | 209-216 |
Number of pages | 8 |
Journal | Carbohydrate Polymers |
Volume | 174 |
DOIs | |
Publication status | Published - 15 Oct 2017 |
Keywords
- Chitosan
- Curdlan sulfate
- Drug delivery
- Nanocarrier
- Polyelectrolyte complex
- Zidovudine
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry