Constructing a Sustainable Cross-Border Scientific Research Collaboration System: Insights from the Shenzhen–Hong Kong Collaboration

The growing importance of cross-border scientific collaboration reflects its role in strengthening regional innovation systems and supporting sustainable socio-economic development. This study examines cross-border scientific research collaboration between Shenzhen and Hong Kong, with particular attention to how institutional differences impact the sustainable development of such cooperation. Drawing on the analytical framework of the cross-border regional innovation systems (CBRIS), this study employs qualitative research methods—including fieldwork interviews, focus groups, and thematic workshops—to systematically examine the key challenges and emerging opportunities arising from institutional differences between the two regions. The findings show that there are significant institutional differences in four areas, including research integrity systems, scientific resource sharing mechanisms, project management processes, and talent development frameworks. These distinctions not only undermine the effectiveness of cross-border collaboration, but they also offer opportunities for institutional coordination and policy innovation meant to promote a more inclusive and sustainable regional research cooperation system. By analysing the experiences of researchers and research administrators, the study emphasises the crucial importance of institutional coordination in ensuring the long-term sustainability of the CBRIS. The results offer data-based evidence and policy insights that can inform the development of policy innovations to strengthen cross-border scientific collaboration and promote the sustainable evolution of the CBRIS.